Dr. rer. nat. Universität Heidelberg
Postdoctoral and research fellow: Institute of Genetics, Universität Köln and MPI für Biologie, Tübingen.
Head of the department for Cytogenetics, GBF, Braunschweig.
At the ZMBH since 1986
Im Neuenheimer Feld 282
Tel: - 49 - 6221 - 54 6880
Fax: - 49 - 6221 - 54 5893
Intercellular signalling and morphogenesis
of the myxobacterium Stigmatella aurantiaca
Stigmatella aurantica is a myxobacterium, which lives in swarms on solid organic matter that the cells degrade by secreted lytic enzymes. The organism survives periods of starvation by undergoing a developmental process in which the individual cells of a swarm aggregate to form multicellular fruiting bodies. When nutrients are supplied again, the myxospores of the fruiting body germinate to build up a new swarm of vegetative cells. The switch from the socially living single cell to the multicellular fruiting body is a prokaryotic paradigm for differentiation processes and signal transduction. Our work on Stigmatella focusses on signalling molecules that co-ordinate fruiting body formation and on genes involved in morphogenesis.
Molecular biology of infection by the entomopathogenic fungus Beauveria bassiana
The filamentous fungus Beauveria bassiana belongs
to a class of insect pathogenic hyphomycetes. The
different Beauveria strains are highly adapted to
particular hostinsects. In the absenceof the host, the facultative insect pathogen passes through an asexual vegetative life cycle. During the infectious process fungal structures are subject to defense response mechanisms of the host-insect.
Our main aim in Beauveria research is the characterization of genes involved in virulence and host-specificity and the analysis of the infectious process.
Members of the Lab Current Research Forschungsthematik Selected Publications Positions ZMBH