Ruprecht-Karls-Universität Heidelberg

Publications by the Luke lab

Search for recent publications by the Luke lab.


Klermund J, Bender K, Luke B: High nutrient levels and TORC1 activity reduce cell viability following prolonged telomere dysfunction and cell cycle arrest. Cell Reports, 2014; In Press (full article)

Maicher A, Lockhart A, Luke B: Breaking new ground: Digging into TERRA function. Biochim Biophys Acta, 2014, Apr 1; 1839(5):387-394 (see Abstract)

Balk B, Dees M, Bender K and Luke B: The differential processing of telomeres in response to increased telomeric transcription and RNA-DNA hybrid accumulation. RNA Biol. 2014, Feb 5; 11(2). (see Abstract)

Balk B*, Maicher A*, Klermund J, Luke-Glaser S, Dees M, Bender K and Luke B: Telomeric RNA-DNA hybrids affect telomere length dynamics and senescence. Nat. Struct. Mol. Biol. 2013, DOI: 10.1038. (see Abstract)

Luke-Glaser S, Poschke H and Luke B: Getting in (and out of) the loop: regulating higher order telomere structures. Frontiers in Oncology. 2012

Poschke H*, Dees M*, Chang M, Kaderali L, Amberkar S, Rothstein R und Luke B: Rif2 promotes a telomere fold-back structure through Rpd3L recruitment in budding yeast. PLoS Genetics. 2012 Sep;8(9):e1002960. (see Abstract)

Luke-Glaser S und Luke B: The budding yeast helicase Mph1 impairs growth when telomere intergrity is compromised. PLoS One. 2012 July 27;7(7):e42028.

Maicher A*, Kastner L*, and Luke B: Telomeres and Disease - Enter TERRA. RNA Biology. 2012 Jun 1;9(6):843-9. (see Abstract).

Maicher A, Kastner L, Dees M and Luke B: Deregulated telomere transcription causes replication dependent telomere shortening and promotes cellular senescence. Nucleic Acids Research. 2012 Aug;40(14):6649-59. (see Abstract).

Ferreira H, Luke B, Schober H, Kalck V, Lingner J and Gasser S: PIAS-homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast. Nature Cell Biol. 2011 Jun 12;13(7):867-74. (see Abstract).

Iglesias N, Redon S, Pfeiffer V, Dees M, Lingner J*, Luke B*: Subtelomeric repetitive elements determine TERRA regulation by Rap1/Rif and Rap1/Sir complexes in yeast. EMBO Rep. 2011 Jun;12(6):587-93. (see Abstract).

Luke-Glaser S, Luke B, Grossi S and Constantinou A: FANCM regulates DNA chain elongation and is stabilized by S-phase checkpoint signalling. EMBO J. 2010 Feb 17;29(4): 795-805. (see Abstract).

Chang M, Luke B, Kraft C, Li Z, Peter M, Lingner M and Rothstein R: Telomerase is essential to alleviate Pif1-induced replication stress at telomeres. Genetics. 2009 Nov;183(3):779-91. (see Abstract).

Luke B and Lingner J: TERRA: telomere repeat containing RNA. EMBO J. 2009 Sep 2;28(17):2503-10. Review (see Abstract).

Deplazes A, Möckli N, Luke B, Auerbach D and Peter M: Yeast Uri1 promotes translation initiation and may provide a link to cotranslational quality control. EMBO J. 2009 May 20;28(10):1429-41. (see Abstract).

Luke B, Panza A,  Redon S, Iglesias N, Li Z, and Lingner J: The Rat1p 5’ to 3’ exonuclease degrades telomeric transcripts and promotes telomere elongation in S. cerevisiae.  Mol Cell. 2008 Nov 21;32(4):465-77. (see Abstract).

Zaidi IW*, Rabut G*, Poveda A , Scheel H, Hofmann K, Pasero P, Malmström J, Ulrich H, Peter M, and Luke B: Rtt101p and Mms1p form a Cul4Ddb1-like E3 ligase which promotes replication through damaged DNA.  EMBO Rep. 2008 Oct;9(10):1034-40. (see Abstract).

Luke B*, Azzalin C*, Hug N, Deplazes A, Peter M and Lingner J: Saccharomyces cerevisiae  Ebs1p is a putative ortholog of human SMG7 and promotes nonsense mediated mRNA decay. Nucleic Acid Res. 2007;35(22):7688-97. (see Abstract).

Luke B, Versini G, Jaquenoud M, Zaidi IW, Kurz T, Pintard L, Pasero P, Peter M,: The cullin Rtt101p promotes replication fork progression through damaged DNA and natural pause sites. Curr Biol. 2006 Apr 18;16(8):786-92. (see Abstract).

Blake D, Luke B, Kanellis P, Jorgensen P, Goh T, Penfold S, Breitkreutz BJ, Durocher D, Peter M, Tyers M,:  The F-box protein Dia2 overcomes replication impedance to promote genome stability in Saccharomyces cerevisiae. Genetics. 2006 Dec;174(4):1709-27. (see Abstract).

Kurz T, Ozlu N, Rudolf F, O’Rourke SM, Luke B, Hofmann K, Hyman AA, Bowermann B, Peter M: The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. Nature. 2005 Jun 30;435(7046):1257-61. (see Abstract).

Gstaiger M, Luke B, Hess D, Oakeley EJ, Wirbelauer C, Blondel M, Vigneron M, Peter M, Krek W: Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI. Science. 2003 Nov 14;302(5648):1208-12. (see Abstract).

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