Hermann Bujard

Professor of Molecular Biology
Dr. rer. nat., Dr. med. h. c.
1962 Dr.rer.nat. in Organic Chemistry, with Hans Brockmannm, Universität Göttingen, Germany
1964/65 NIH Postdoctoral Fellow, McArdle, University of Wisconsin, Madison, USA
1966/69 Assistant Professor, Southwest Center for Advanced Studies, Dallas, Texas, USA
1970/82 Professor at the Institute für Molekulare Genetik, Universität Heidelberg, Germany
1983/86 Head of Biological Research and Deputy Director, F. Hoffmann-La Roche & Co., Basel, Switzerland
1986-now ZMBH, Universität Heidelberg
Hermann Bujard
ZMBH, Im Neuenheimer Feld 282
69120 Heidelberg, Germany
Tel.: + 49-6221 54 8214
Fax.: +49-6221 54 5892
E-mail: h.bujard@zmbh.uni-heidelberg.de

 Malaria: The Merozoite Surface Protein 1 (MSP-1) Plasmodium falciparum.

The MSP-1 complex of the human malaria parasite P. falciparum which originates from a 190 kDa precursor by proteolytic processing is the major protein component at the surface of merozoites, the erythrocyte invading form of the parasite. It appears involved in essential steps of the invasion process and a number of findings make it a promising candidate for a subunit vaccine against malaria tropica. We are interested in (1) examining the potential of MSP-1 in eliciting a protective immune response in humans; (2) structure/function relationships of this intriguing protein.

Control of Gene Expression in Eukaryotes via Tetracyclines

The Tet regulatory systems developed in our lab have been widely applied in a variety of cultured cells as well as in many biological model organisms. Our interest focusses on applying Tet regulation in the mouse in a quantitative and predictable manner. Thus, we are interested in questions of locus control and stringency of regulation. The insights gained are being applied in several mouse models for human diseases, as well as in the control of genes involved in synaptic plasticity of the mouse brain. Several topics are pursued in the context of collaborations.


download Hermann Bujard´s Annual Report 2002 (pdf)







Structure of the group

Tet regulatory systems



Summary of the current research activities