Ruprecht-Karls-Universität Heidelberg

Publications by the Edgar Lab

Search pubmed for publications by Bruce Edgar

Jiang, H., Grenley, M.O., Bravo, M.J., Blumhagen, R.Z., and Edgar, B.A. (2011). EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila. Cell Stem Cell 8:84-95.

Li, L., Edgar, B.A., and Grewal, S.S. (2011). Nutritional control of gene expression in Drosophila larvae via TOR, Myc and a novel cis-regulatory element. BMC Cell Biol 11:7.

O'Keefe, D.D., Edgar, B.A., and Saucedo, L.J. (2010). EndoGI modulates Notch signaling and axon guidance in Drosophila. Mech Dev 128:59-70.

Shaw, R.L., Kohlmaier, A., Polesello, C., Veelken, C., Edgar, B.A., and Tapon, N. (2010). The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration. Development 137:4147-4158.

Buttitta, L.A., Katzaroff, A.J., and Edgar, B.A. (2010). A robust cell cycle control mechanism limits E2F-induced proliferation of terminally differentiated cells in vivo. J Cell Biol 189:981-996.

Wang, T., Lao, U., Edgar, B. A. (2009) TOR-mediated autophagy regulates cell death in Drosophila neurodegenerative disease. J. Cell Biol. 186:703-711.

O'Keefe, D. D., Gonzalez-Niño, E, Burnett. M., Dylla, L.,  Lambeth, S. M., Licon, E., Amesoli, C., Edgar, B. A., Curtiss, J. (2009) Rap1 maintains adhesion between cells to affect Egfr signaling and planar cell polarity in Drosophila. Developmental Biol. 333:143-160.

Jiang, H., Patel, P. H., Kohlmaier, A., Grenley, M. O., McEwen, D., and Edgar, B. A. (2009) Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell 137:1343-1355.

Jiang, H., and Edgar, B.A. (2009). EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors. Development 136:483-493.

Shibutani, S.T., de la Cruz, A.F., Tran, V., Turbyfill, W.J., Reis, T., Edgar, B.A., and Duronio, R.J. (2008) Intrinsic negative cell cycle regulation provided by PIP box- and Cul4Cdt2-mediated destruction of E2f1 during S phase. Developmental Cell 15:890-900.

Oren-Giladi, P., Krieger, O., Edgar, B. A., Chamovitz, D. A., Segal, D. The Cop9 signalosome subunit 8 (CSN8) is essential for Drosophila development. (2008) Genes to Cells, (3):221-231.

Grewal, S.S., Evans, J.R., Edgar, B.A. (2007) Drosophila TIF-IA is required for ribosome synthesis and cell growth and is regulated by the TOR pathway. The Journal of Cell Biology, 179 (6):1105-13.

O'Keefe, D.D., Prober, D.A., Moyle, P.S., Rickoll, W.L., Edgar, B.A. (2007) Egfr/Ras signaling regulates DE-cadherin/Shotgun localization to control vein morphogenesis in the Drosophila wing. Developmental biology, 311 (1):25-39.

Buttitta, L., Katzaroff, A., Perez, C., de la Cruz, A., Edgar, B.A. (2007) A double-assurance mechanism controls cell cycle exit upon terminal differentiation in Drosophila. Dev. Cell 12:631-643.

Hall, D., Grewal, S., de la Cruz, A., Edgar, B.A. (2007) Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila. BMC Biol. 19:5-10.

Oron, E., Tuller, T. Li, L. Rozovsky, N., Yekutieli, D. Segal, D., Chor, B., Edgar, B. A., Chamovitz, D. A., (2007) Genomic analysis of COP9 signalsome function in Drosophila melanogaster reveals a tole in temporal regulation of gene expression.  Mol Syst Biol. 3:108.

Datar S.A., Galloni M., de la Cruz A., Marti M., Edgar, B.A., Frei C. (2006). Mammalian Cyclin D1/Cdk4 complexes induce cell growth in Drosophila. Cell Cycle 5:647-652.

Orian A., Grewal S. S., Knoepfler P.S., Edgar B. A., Parkhurst S. M., Eisenman R. N. (2005). Genomic binding and transcriptional regulation by the Drosophila myc and mnt transcription factors. Cold Spring Harb, Symp. Quant. Biol. 70:1-10.

Loo, L. L. M., Secombe, J., Little, J. T., Carlos, L. S., Yost, C., Cheng, P. F., Flynn, E. M., Edgar B. A., Eisenman, R. L. (2005) The Transcriptional Repressor, dMnt, is a Regulator of Growth in Drosophila. Mol Cell Biol 25:7078-7091.

Grewal, S.S., Li, L., Orian, A., Eisenman, R.N., Edgar, B.A. (2005) Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development. Nat Cell Biol 7: 295-302.

Frei, C., Galloni, M., Hafen, E., Edgar, B.A. (2005) The Drosophila mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4-driven growth. EMBO J 24: 623-634.

Emmerich, J., Meyer, C. A., de la Cruz, A. F., Edgar, B. A., and Lehner, C. F. (2004) Cyclin D does not provide essential Cdk4-independent functions in Drosophila. Genetics 168: 867-875.

Reis, T., and Edgar, B. A. (2004) Negative regulation of dE2F1 by Cyclin dependent kinases controls cell cycle timing. Cell 117: 253-264.

Pierce, S. B., Yost, C., Britton, J. S., Flynn, E. M., Edgar, B. A., and Eisenman, R. N. (2004) dMyc is required for larval growth and endoreplication in Drosophila. Development 131: 2317-2327.

Frei, C. and Edgar, B. A. (2004) Drosophila Cyclin D/Cdk4 Requires Hif-1 Prolyl Hydroxylase to Drive Cell Growth. Developmental Cell 6: 241-251.

Zhang, Y., Gao, X., Saucedo, L. J., Ru, B., Edgar, B. A., and Pan, D. (2003) Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat Cell Biol 5: 578-581.

Saucedo, L. J., Gao, X., Chiarelli, D. A., Li, L., Pan, D., and Edgar, B. A. (2003) Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat Cell Biol 5: 566-571.

Orian, A., Van Steensel, B., Delrow, J., Bussemaker, H. J., Li, L., Sawado, T., Williams, E., Loo, L. W., Cowley, S. M., Yost, C., et al. (2003) Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network. Genes Dev 17: 1101-1114.

Prober, D.A. and Edgar, B.A. (2002) Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing. Genes & Development 16, 2286-2299.

Martín-Castellanos, C. and Edgar, B.A. (2002) A characterization of the effects of Dpp signaling on cell growth and proliferation in the Drosophila wing. Development 129, 1003-1013.

Britton, J.S., Lockwood, W.B., Cohen, S.M., and Edgar, B.A.  (2002) Drosophila’s Insulin/PI3-Kinase Pathway Coordinates Cellular Metabolism with Nutritional Conditions. Developmental Cell 2, 239–249

Frank D.J., Edgar B.A., Roth M.B. (2002) The Drosophila melanogaster gene brain tumor negatively regulates cell growth and ribosomal RNA synthesis. Development 129, 399-407.

Datar, S.A., Jacobs, H.W., de la Cruz, A.F.A., Lehner, C.F., and Edgar, B.A.  (2000)  The Drosophila Cyclin D-Cdk4 complex promotes cellular growth. EMBO J 19, 4543-4554.

Meyer, C.A., Jacobs, H.W., Datar, S.A., Du, W., Edgar, B.A., and Lehner, C.F.  (2000)  Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression.  EMBO J 19, 4533-4542.

Prober, D.A. and Edgar, B.A. (2000)  Ras promotes cellular growth in the Drosophila wing. Cell 100, 435-446.

Johnston, L.A., Prober, D.A., Edgar, B.A., Eisenman, R.N., and Gallant, P.  (1999)  Drosophila myc regulates cellular growth during development.  Cell 98, 779-790.

Migeon, J.C., Garfinkel, M.S., and Edgar, B.A.  (1999)  Cloning and characterization of peter pan, a novel Drosophila gene required for larval growth.  Mol Biol Cell 10, 1733-1744.

Galloni, M. and Edgar, B.A.  (1999)  Cell-autonomous and non-autonomous growth-defective mutants of Drosophila melanogaster. Development 126, 2365-2375.

Lehman, D.A., Patterson, B., Johnston, L.A., Balzer, T., Britton, J.S., Saint, R. and Edgar, B.A.  (1999)  Cis-regulatory elements of the mitotic regulator, string/Cdc25.  Development 126, 1793-1803.

Neufeld, T.P., de la Cruz, A.F.A., Johnston, L.A., and Edgar, B.A.  (1998)  Coordination of growth and cell division in the Drosophila wing.  Cell 93, 1183-1193.

Johnston, L.A., and Edgar, B.A.  (1998)  Wingless and Notch regulate cell-cycle arrest in the developing Drosophila wing.  Nature 394, 82-84.

Britton, J.S. and Edgar, B.A.  (1998)  Environmental control of the cell cycle in Drosophila: nutrition activates mitotic and endoreplicative cells by distinct mechanisms.  Development 125, 2149-2158.

Edgar, B.A. and Datar, S.  (1996)  Zygotic degradation of two maternal Cdc25 mRNAs terminates Drosophila's early cell cycle program.  Genes Dev 10, 1966-1977.

Campbell, S.D., Edgar, B.A. and O'Farrell, P.H.  (1995)  Drosophila Wee1 kinase rescues fission yeast from mitotic catastrophe and phosphorylates Drosophila Cdc2 in vitro.  Mol Biol Cell 6, 1333-1347.

Edgar, B.A., Lehman, D. and O'Farrell, P.H.  (1994)  Transcriptional regulation of string (cdc25):  a link between developmental programming and the cell-cycle.  Development 120:3131-3143.

Edwards, K.A., Montague, R.A., Shepard, S., Edgar, B.A., Erikson, R.L. and Kiehart, D.P.  (1994)  Identification of Drosophila cytoskeletal proteins by induction of abnormal cell shape in fission yeast.  Proc Natl Acad Sci USA 91, 4589-4593.

Moreno S, Nurse P. (1994). Regulation of progression through the G1 phase of the cell cycle by the rum1+ gene.  Nature 367:236-42.   (Dr. Edgar was inadvertently omitted as second author of this paper).

Edgar, B.A., Sprenger, F., Duronio, R.J., Leopold, P. and O'Farrell, P.  (1994)  Distinct molecular mechanisms regulate cell cycle timing at successive stages of Drosophila embryogenesis.  Genes Dev 8, 440-452.

Edgar, B.A. and O'Farrell, P.H.  (1990)  The three postblastoderm cell cycles of Drosophila embryogenesis are regulated in G2 by string.  Cell 62, 469-480.

Edgar, B.A. and O'Farrell, P.H.  (1989)  Genetic control of cell division patterns in the Drosophila embryo.  Cell 57, 177-187.

Edgar, B.A., Odell, G.M. and Schubiger, G.  (1989)  A genetic switch, based on negative regulation, sharpens stripes in Drosophila embryos.  Dev Genet 10, 124-142.

Weir, M.P., Edgar, B.A., Kornberg, T. and Schubiger, G.  (1988)  Spatial regulation of engrailed expression in the Drosophila embryo.  Genes Dev 2, 1194-1203.

Edgar, B.A., Odell, G.M. and Schubiger, G.  (1987)  Cytoarchitecture and the patterning of fushi tarazu expression in the Drosophila blastoderm.  Genes Dev 1, 1126-1247.

Edgar, B.A., Weir, M.P., Schubiger, G. and Kornberg, T.  (1986)  Repression and turnover pattern fushi tarazu RNA in the early Drosophila embryo.  Cell 47, 747-754.

Edgar, B.A. and Schubiger, G.  (1986)  Parameters controlling transcriptional activation during early Drosophila development.  Cell 44, 871-877.

Edgar, B.A., Kiehle, C.P. and Schubiger, G.  (1986)  Cell cycle control by the nucleo-cytoplasmic ratio in early Drosophila development.  Cell 44, 365-372.

Payvar, F., DeFranco, D., Firestone, G.L., Edgar, B.A., Wrange, O., Orket, S., Gustafsson, J. and Yammamoto, K.R.  (1983)  Sequence-specific binding of  glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region.  Cell 35, 381-392.

Shinedling, S., Singer, B.S., Gayle, M., Pribnow, D., Jarvis, E., Edgar, B., and Gold, L.  (1987)  Sequences and studies of bacteriophage T4 rII mutants.  J Mol Biol 195, 471-480.

Reviews and commentaries

Edgar, B. A. and Kim, K., J. (2009) Sizing up the cell. Science 325: 158-159.

Kohlmaier, A., Edgar, B.A. (2008) Proliferative control in Drosophila stem cells. Curr. Opin. Cell Biol, 20:699-706.

Bandura, J.L., Edgar, B. A. (2008) Yorkie and Scalloped, partners in growth activation. Dev. Cell 14;315-316. (Review).

Buttitta, L.A., Edgar, B.A. (2007) Mechanisms controlling cell cycle exit upon terminal differentiation. Current Opinion in Cell Biology, 19 (6), 697-704. (Review).

Buttitta, L.A., Edgar, B.A. (2007) How size is controlled: from Hippos to Yorkies. Nature Cell Biology, 9 (11), 1225-7. (Review).

Saucedo, L. J., Edgar, B. A. (2007) Filling out the Hippo pathway. Nat. Rev. Mol. Cell Biol. 8 (8), 613-621. (Review).

Edgar, B. A. (2006). How flies get their size: genetics meets physiology. Nat. Rev. Genet. 7:907-916 (Review).

Edgar, B. A. (2006). From Cell structure to transcription: Hippo forges a new path. Cell 124:267-273. (Review).

Grewal, S.S. and Edgar, B.A. (2003) Controlling cell division in yeast and animals: does size matter? Journal of Biology 2:5. (Review).

Saucedo L.J. and Edgar, B.A. (2002) Why size matters: altering cell size. Curr Opin Genet Dev 12, 565-571. (Review).

Edgar, B.A. and Orr-Weaver, T.L.  (2001)  Endoreplication cell cycles: more for less.  Cell 105, 297-306. (Review).

Prober, D.A. and Edgar B.A. (2001)  Growth regulation by oncogenes – new insights from model organisms.  Curr Opin Genet Dev 11, 19-26. (Review).

Edgar, B.A.  (1999)  From small flies come big discoveries about size control.  Nature Cell Biol 1, E191-E193. (Review).

Neufeld, T.P. and Edgar, B.A. (1998) Connections between growth and the cell cycle. Curr Opin Cell Biol 10, 784-790. (Review).

Edgar, B.A. and Lehner, C.F. (1996)  Developmental control of cell cycle regulators:  A fly’s perspective  Science 274, 1646-1652. (Review).

Edgar, B.A.  (1995)  Diversification of cell cycle controls in developing embryos.  Curr Opin Cell Biol 7, 815-824. (Review).

Edgar, B.A.  (1994)  Cell-cycle control in a developmental context.  Curr Biol 4, 522-524. (Review).

O'Farrell, P.H., Edgar, B.A., Lakich, D. and Lehner, C.F.  (1989)  Directing cell division during development.  Science 246, 635-640. (Review).

Book chapters

de la Cruz, A. F., Edgar, B. A. (2008). Flow cytometry of Drosophila cells. Methods in Mol. Biol. 420, 373-389.

Edgar, B. and Nijhout, H.F. (2004) Growth and Cell Cycle Control in Drosophila. In: Cell Growth: Control of Cell Size, M.N. Hall, M. Raff, and G. Thomas, eds. Cold Spring Harbor Laboratory Press,  pp. 23-83.

Edgar, B.A., Britton, J., de la Cruz, A.F.A., Johnston, L.A., Lehman, D., Martin-Castellanos, C., and Prober, D. (2001)  Pattern- and growth-linked cell cycles in Drosophila development. In: “The Cell Cycle and Development”. John Wiley & Sons (Novartis Found. Symp. 237:3-12).

Schubiger, G. and Edgar, B.  (1994)  Using Inhibitors to Study Embryogenesis.  In:  "Drosophila melanogaster:  Practical Uses in Cell Biology."  Meth. Cell Biol. 44, 697-713.

Foe, V.E., Odell, G.M. and Edgar, B.A.  (1993)  Mitosis and morphogenesis in the Drosophila embryo: Point and counterpoint.  In: The Development of Drosophila melanogaster, M. Bate and A. Martinez Arias, eds. Cold Spring Harbor Laboratory Press, pp. 149-300.

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