Publications by the Lemberg Laboratory


Search Pubmed for publications by Marius Lemberg


Lemberg MK, Freeman M. Functional and evolutionary implications of enhanced genomic analysis of rhomboid intramembrane proteases. Genome Res. 17: 1634-1646. (2007)

Lemberg, MK, Freeman M. Cutting proteins within lipid bilayers: rhomboid structure and mechanism. Mol. Cell. 28: 930-940. (2007)

Lemberg MK, Menendez J, Misik A, Garcia M, Koth CM, Freeman M.Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases. EMBO J. 24: 464-472. (2005)

Friedmann E, Lemberg MK, Weihofen A, Dev KK, Dengler U, Rovelli G, Martoglio B. Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins. J. Biol. Chem. 279: 50790-50798. (2004)

Lemberg MK, Martoglio B. On the mechanism of SPP-catalysed intramembrane proteolysis; conformational control of peptide bond hydrolysis in the plane of the membrane. FEBS Lett. 564: 213-218. (2004)

Bland FA, Lemberg MK, McMichael A, Martoglio B, Braud VM. Requirement of the proteasome for the trimming of signal peptide-derived epitopes presented by the nonclassical MHC class I molecule HLA-E. J. Biol. Chem. 278: 16528-16533. (2003)

Lemberg MK, Martoglio B. Analysis of polypeptides by SDS-PAGE alongside in vitro generated reference peptides. Anal. Biochem., 319: 327-331. (2003)

Weihofen A, Lemberg MK, Friedmann E, Rueeger H, Schmitz A, Paganetti P, Rovelli G, Martoglio B. Targeting Presenilin-type Aspartic Protease Signal Peptide Peptidase with g-Secretase Inhibitors. J. Biol. Chem. 278: 16528-16533. (2003)

Lemberg MK, Martoglio B. Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis. Mol. Cell 10: 735-744. (2002)

McLauchlan J, Lemberg MK, Hope G, Martoglio B. Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets. EMBO J. 21: 3980-3988. (2002)

Weihofen A, Binns K, Lemberg MK, Ashman K, Martoglio B. Identification of signal peptide peptidase, a presenilin-type aspartic protease. Science 296: 2215-2218. (2002)

Lemberg MK, Bland FA, Weihofen A, Braud VM, Martoglio B. Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes. J. Immunol. 167: 6441-6446. (2001)

Weihofen A, Lemberg MK, Ploegh HL, Bogyo M, Martoglio B. Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor. J. Biol. Chem. 275: 30951-30956. (2000)