Ruprecht-Karls-Universität Heidelberg

Publications by the Lemberg Lab

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Kronenberg-Versteeg, D, Eichmann, M, Russell, MA, de Ru, A, Hehn, B, Yusuf, N, van Veelen, PA, Richardson, SJ, Morgan, NG, Lemberg, MK, Peakman, M. Molecular pathways for immune recognition of preproinsulin signal peptide in type 1 Diabetes. Diabetes (2018)

Avci, D, Lemberg MK. Membrane Protein Dislocation by the Rhomboid Pseudoprotease Dfm1: No Pore Needed? Mol. Cell. 69, 161-162 (2018)

Cordier, B., and Lemberg, M.K. Probing the activity of eukaryotic rhomboid proteases in vitro. In: Enzymology at the Membrane Interface: Intramembrane Proteases. Methods in Enzymology 584, 99-126. (2017)

Malchus NS, Lemberg MK. Proteolyse in der Membran – Schutz für die Proteinhomöostase. Biospektrum 22:582-584. (2016)

Nilse L, Avci D, Heisterkamp P, Serang O, Lemberg MK, Schilling O. Yeast membrane proteomics using leucine metabolic labelling: bioinformatic data processing and exemplary application to the ER-intramembrane protease Ypf1. Biochim. Biophys. Acta. 1864:1363-1371. (2016)

Lemberg MK, Adrain C. Inactive Rhomboid Proteins: New Mechanisms with Implications in Health and Disease. Semin. Cell Dev. Biol. (2016)

Wunderle L, Knopf JD, Kühnle N, Morle A, Hehn B, Adrain C, Strisovsky K, Freeman M, Lemberg MK. Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGF-alpha. Sci. Rep. 6: 27342. (2016)

Klinosky D.J. et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12, 1-222. (2016)

Khmelinskii, A., Meurer, M., Ho, C.T., Besenbeck, B., Füller, J., Lemberg, M.K., Bukau, B., Mogk, A., Knop, M. Incomplete proteasomal degradation of green fluorescent proteins in the context of tandem fluorescent protein timers. MBoC 27, 360-370. (2016)

Avci D, Lemberg MK. Clipping or Extracting: Two ways to Membrane Protein Degradation. Trends Cell Biol. 25: 611-622. (2015)

Meissner C, Lorenz H, Hehn B, Lemberg MK. Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy. Autophagy. 11: 1484-1498. (2015)

Langosch D, Scharnagl C, Steiner H, Lemberg MK. Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics. Trends Biochem. Science. 40:318-327. (2015)

Avci D, Fuchs S, Schrul B, Fukumori A, Breker M, Frumkin I, Chen C, Biniossek ML, Kremmer E, Schilling O, Steiner H, Schuldiner M, Lemberg MK. The yeast ER-intramembrane protease Ypf1 refines nutrient sensing by regulating transporter abundance. Mol.Cell.56:630-640 (2014)

Chen C, Malchus NS, Hehn B, Stelzer W, Avci D, Langosch D, Lemberg MK. Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u. EMBO J. 33: 2492-2506. (2014)

Bergbold N, Lemberg MK. Emerging role of rhomboid family proteins in mammalian biology and disease. BBA - Biomembranes. 1828: 2840-2848. (2013)

Lemberg, MK, Sampling the Membrane: Function of Rhomboid-Family Proteins. Trends Cell Biol. 23: 210-217. (2013)

Fleig L, Bergbold N, Sahasrabudhe P, Geiger B, Kaltak L, Lemberg MK. Ubiquitin-Dependent Intramembrane Rhomboid Protease Promotes ERAD of Membrane Proteins. Mol Cell. 47: 558-569. (2012) Highlighted by News and Views in Nat. Struct. Mol. Biol., Preview in Dev. Cell and Faculty of 1000

Prod´home V, Tomasec P, Cunningham C, Lemberg MK, Stanton RJ, McSharry BP, Wang EC, Cuff S, Martoglio B, Davison AJ, Braud VM, Wilkinson GWG. Human Cytomegalovirus UL40 Signal Sequence Regulates Cell Surface Expression of the Natural Killer Cell Ligands HLA-E and gpUL18. J. Immunol. 188: 2794-2804. (2012)

Lemberg, MK. Intramembrane proteolysis in regulated protein trafficking. Traffic. 12: 1109-1118. (2011)

Adrain C, Strisovsky, Zettl M, Hu L, Lemberg MK, Freeman M. Mammalian EGF receptor activation by the rhomboid protease RHBDL2. EMBO Rep. 12: 421-427. (2011)

Meissner C, Lorenz H, Weihofen A, Selkoe DJ, Lemberg MK. The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking. J. Neurochem. 117:856-867. (2011)

Kapp K, Schrempf S, Lemberg MK, Dobberstein B. Post-targeting functions of signal peptides. In: Protein Transport into the Endoplasmic Reticulum, Ed. R. Zimmermann, Landes Bioscience (2009) Open access:

Lemberg MK, Freeman M. Functional and evolutionary implications of enhanced genomic analysis of rhomboid intramembrane proteases. Genome Res. 17: 1634-1646. (2007)

Lemberg, MK, Freeman M. Cutting proteins within lipid bilayers: rhomboid structure and mechanism. Mol. Cell. 28: 930-940. (2007)

Lemberg MK, Menendez J, Misik A, Garcia M, Koth CM, Freeman M. Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases. EMBO J. 24: 464-472. (2005)

Friedmann E, Lemberg MK, Weihofen A, Dev KK, Dengler U, Rovelli G, Martoglio B. Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins. J. Biol. Chem. 279: 50790-50798. (2004)

Lemberg MK, Martoglio B. On the mechanism of SPP-catalysed intramembrane proteolysis; conformational control of peptide bond hydrolysis in the plane of the membrane. FEBS Lett. 564: 213-218. (2004)

Bland FA, Lemberg MK, McMichael A, Martoglio B, Braud VM. Requirement of the proteasome for the trimming of signal peptide-derived epitopes presented by the nonclassical MHC class I molecule HLA-E. J. Biol. Chem. 278: 16528-16533. (2003)

Lemberg MK, Martoglio B. Analysis of polypeptides by SDS-PAGE alongside in vitro generated reference peptides. Anal. Biochem., 319: 327-331. (2003)

Weihofen A, Lemberg MK, Friedmann E, Rueeger H, Schmitz A, Paganetti P, Rovelli G, Martoglio B. Targeting Presenilin-type Aspartic Protease Signal Peptide Peptidase with g-Secretase Inhibitors. J. Biol. Chem. 278: 16528-16533. (2003)

Lemberg MK, Martoglio B. Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis. Mol. Cell 10: 735-744. (2002) Read the Mol. Cell Preview / Recommended by the Faculty of 1000

McLauchlan J, Lemberg MK, Hope G, Martoglio B. Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets. EMBO J. 21: 3980-3988. (2002)

Weihofen A, Binns K, Lemberg MK, Ashman K, Martoglio B. Identification of signal peptide peptidase, a presenilin-type aspartic protease. Science 296: 2215-2218. (2002) Read the Science Perspective
/ Recommended by the Faculty of 1000

Lemberg MK, Bland FA, Weihofen A, Braud VM, Martoglio B. Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes. J. Immunol. 167: 6441-6446. (2001) Recommended by the Faculty of 1000

Weihofen A, Lemberg MK, Ploegh HL, Bogyo M, Martoglio B. Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor. J. Biol. Chem. 275: 30951-30956. (2000)




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