Ruprecht-Karls-Universität Heidelberg

Publications during the second funding period (July 1, 2016 - June 30, 2020)


Shiber, A., Döring, K., Friedrich, U., Klann, K., Merker, D., Zedan, M., Tippmann, F., Kramer, G., Bukau, B. (2018) Co-translational assembly of protein complexes in eukaryotes revealed by ribosome profiling. Nature, accepted.

Koskela, M.M., Brünje, A., Ivanauskaite, A., Grabsztunowicz, M., Lassowskat, I., Neumann, U., Dinh, T.V., Sindlinger, J., Schwarzer, D., Wirtz, M., Tyystjärvi, E., Finkemeier, I. and Paula Mulo, P. (2018) Chloroplast acetyltransferase NSI is required for state transitions in Arabidopsis thaliana. Plant Cell., accepted.

Senyilmaz-Tiebe, D., Pfaff, D.H., Virtue, S., Schwarz, K.V., Fleming, T., Altamura, S., Muckenthaler, M.U., Okun, J.G., Vidal-Puig, A., Naworth, P., Teleman A.A. (2018) Dietary stearic acid regulates mitochondria in vivo in humans. (2018). Nature Comm., in Press.

Meurer, M., Duan, Y., Sass, E., Kats, I., Herbst, K., Buchmuller, B.C., Dederer, V., Huber, F., Kirrmaier, D., Stefl, M., Laer, K.V., Dick, T.P., Lemberg, M.K., Khmelinskii, A., Levy, E.D., Knop, M. (2018) Genome-wide C-SWAT library for high-throughput yeast genome tagging. Nature Meth., in press.

Zhao, Z., Sentürk, N., Song, C., Grummt, I. (2018) lncRNA PAPAS tethered to the rDNA enhancer recruits hypophosphorylated CHD4/NuRD to repress rRNA synthesis at elevated temperatures. Genes Dev. 32:836-848. doi: 10.1101/gad.311688.118. (Abstract).

Németh A, Grummt I. (2018) Dynamic regulation of nucleolar architecture. Curr Opin Cell Biol. 52:105-111. doi: 10.1016/ (Abstract).

Kowalski, L., Bragoszewski, P., Khmelinskii, A., Glow, E., Knop, M., Chacinska, A. (2018)  Determinants of the cytosolic turnover of mitochondrial intermembrane space proteins. BMC Biol. 16:66. doi: 10.1186/s12915-018-0536-1. (Abstract).

Kats, I., Khmelinskii, A., Kschonsak, M., Huber, F., Knieß, R.A., Bartosik, A., Knop, M. (2018) Mapping degradation signals and pathways in a eukaryotic N-terminome. Mol Cell. 70:488-501.e5. doi: 10.1016/j.molcel.2018.03.033. (Abstract).

Deglasse, J.P., Roma, L.P., Pastor-Flores, D., Gilon, P., Dick, T.P., Jonas, J.C. (2018) Antioxid Redox Signal. 10.1089/ars.2017.7287. (Abstract).

Ezerina, D., Takano, Y., Hanaoka, K., Urano, Y., Dick, T.P. (2018) N-acetyl cysteine functions as a fast-acting antioxidant by triggering intracellular H2S and sulfane sulfur production. Cell Chem Biol 25:447-459 e4. (Abstract).

Garcia del Arco A., Edgar B., Erhardt S. (2018) In vivo analysis of centromeric proteins reveals a stem cell-specific asymmetry and an essential role in differentiated, non-proliferating cells. Cell Rep. doi: 10.1016/j.celrep.2018.01.079. (Abstract).

Ahmed, Y.L., Schleich, S., Bohlen, J., Mandel, N., Simon, B., Sinning, I., Teleman, A.A. (2018). DENR·MCTS1 heterodimerization and tRNA recruitment are required for translation reinitiation. PLoS Biology 16:e2005160. doi: 10.1371/journal.pbio.2005160. (Abstract).

Acevedo, J.M., Hoermann, B., Schlimbach, T., Teleman, A.A. (2018). Changes in global translation elongation or initiation rates shape the proteome via the Kozak sequence. Sci Rep. 8:4018. doi: 10.1038/s41598-018-22330-9. (Abstract).

Moraru, A., Wiederstein, J., Pfaff, D., Fleming, T., Miller, A.K., Nawroth, P., Teleman, A.A. (2018). Elevated levels of the reactive metabolite methylglyoxal recapitulate progression of Type 2 Diabetes. Cell Metab. 27:926-934. doi: 10.1016/j.cmet.2018.02.003. (Abstract).

Grousl, T., Ungelenk, S., Miller, S., Ho, C.T., Khokhrina, M., Mayer, M.P., Bukau, B., Mogk, A. (2018). A prion-like domain in Hsp42 drives chaperone-facilitated aggregation of misfolded proteins. J. Cell Biol. 217:1269-1285. pii: jcb.201708116. doi: 10.1083/jcb.201708116.1. (Abstract).

Avci, D., Lemberg, M.K. (2018). Membrane Protein Dislocation by the Rhomboid Pseudoprotease Dfm1: No Pore Needed? Mol. Cell 69:161-162. doi: 10.1016/j.molcel.2017.12.031. (Abstract).

Mogk, A., Bukau, B., Kampinga, H.H. (2018). Molecular Mechanism of J-Domain-Triggered ATP Hydrolysis by Hsp70 Chaperones. Mol. Cell 214-226. doi: 10.1016/j.molcel.2018.01.004. (Abstract).

Stöcker, S., Maurer, M., Ruppert, T., Dick, T.P. (2018). A role for 2-Cys peroxiredoxins in facilitating cytosolic protein thiol oxidation. Nat. Chem. Biol. 14:148-155. doi:10.1038/nchembio.2536. (Abstract).

Heppner, D.E., Hristova, M., Ida, T., Mijuskovic, A., Dustin, C.M., Bogdandi, V., Fukuto, J.M., Dick, T.P., Nagy, P., Li, J., Akaike, T., van der Vliet, A. (2018). Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling? Redox biology 14, 379-385, doi:10.1016/j.redox.2017.10.006. (Abstract).


Zatorska, E., Gal, L., Schmitt, J., Bausewein, D., Schuldiner, M., Strahl, S. (2017) Cellular consequences of diminished protein O-mannosyltransferase activity in baker's yeast. Int. J. Mol. Sci. 18. pii: E1226. doi: 10.3390/ijms18061226. (Abstract).

Dong, Y., Silbermann, M., Speiser, A., Forieri, I., Linster, E., Poschet, G., Allboje, A., Watanabe, M., Sticht. C., Teleman, A.A., Deragon, J.-M., Saito, K., Hell, R., Wirtz, M. (2017). Sulfur availability regulates plant growth via glucose-TOR signaling. Nature Communications 8:1174 doi: 10.1038/s41467-017-01224-w. (Abstract).

Acharya, S., Hartmann, M., Erhardt, S. Chromatin-associated noncoding RNAs in development and inheritance. Wiley Interdiscip. Rev. RNA. 2017 Aug 25. doi: 10.1002/wrna.1435. (Abstract).

Zhang, Y., Sinning, I., Rospert, S. (2017) Two chaperones locked in an embrace: Structure and function of the ribosome-associated complex RAC, Nat. Struct. Mol. Biol. 24: 611-619. (Abstract).

Mudholkar, K., Fitzke, E., Prinz, C., Mayer, M. P., Rospert, S. (2017) The Hsp70 homolog Ssb affects ribosome biogenesis via the TORC1-Sch9 signaling pathway. Nat Commun. 10.1038/s41467-017-00635-z. (Abstract).

Romero-Pozuelo, J., Demetriades, C., Schröder, P., Teleman, A.A. (2017). CycD/Cdk4 and discontinuities in Dpp signaling activate TORC1 in the Drosophila wing disc. Dev.Cell, 2: 376-87. doi: 10.1016/j.devcel.2017.07.019. (Abstract).

Stöcker, S., Van Laer, K., Mijuskovic, A., Dick, T.P. (2017). The Conundrum of Hydrogen Peroxide Signaling and the Emerging Role of Peroxiredoxins as Redox Relay Hubs. Antioxid Redox Signal, doi:10.1089/ars.2017.7162. (Abstract).

Döring, K., Ahmed, N., Riemer, T., Suresh, H.G., Vainshtein, Y., Habich, M., Riemer, J., Mayer, M.P., O'Brien, E.P., Kramer, G., Bukau, B. (2017). Profiling Ssb-nascent chain interactions reveals principles of Hsp70-assisted folding. Cell 170:298-311.e20. doi: 10.1016/j.cell.2017.06.038. (Abstract).

Book Series "Progress in Molecular and Subcellular Biology", Book title: "Centromeres and Kinetochores", Editor: Ben Black, Chapter 7: "Post-translational modifications of centromeric chromatin" (2017) by Ana García del Arco & Sylvia Erhardt (see more).

Nötzold, L., Frank, L., Gandhi, M., Polycarpou-Schwarz, M., Groß, M., Gunkel, M., Beil, N., Erfle, H., Harder, N., Rohr, K., Trendel, J., Krijgsveld, J., Longerich, T., Schirmacher, P., Boutros, M., Erhardt, S., Diederichs, S. (2017). The long non-coding RNA LINC00152 is essential for cell cycle progression through mitosis in HeLa cells. Sci Rep. 7:2265. doi: 10.1038/s41598-017-02357-0 (Abstract).

Shostak, A., Ruppert, B., Diernfellner, A., Brunner, M. (2017). Correspondence: Reply to 'Oncogenic MYC persistently upregulates the molecular clock component REV-ERBα'. Nat Commun. 8:14918. doi: 10.1038/ncomms14918 (Abstract).

Weyer, F.A., Gumiero, A., Lapouge, K., Bange, G., Kopp, J., Sinning, I. (2017) Structural basis of HypK regulating N-terminal acetylation by the NatA complex. Nat. Comm. 8:15726. doi: 10.1038/ncomms15726 (Abstract).

Meurer, M., Chevyreva, V., Cerulus, B., Knop, M. (2017). The regulatable MAL32 promoter in Saccharomyces cerevisiae: characteristics and tools to facilitate its use. Yeast 34:39-49. doi: 10.1002/yea.3214. PMID: 27714848. (Abstract).

Daturpalli, S., Knieß, R. A., Lee, C.-T., Mayer, M. P. (2017). Large rotation of the N-terminal domain of Hsp90 is important for interaction with some but not all client proteins. J. Mol. Biol. 429:1406-1423. doi:10.1016/j.jmb.2017.03.025 (Abstract).

Nguyen, M.T.N., Knieß, R.A., Daturpalli, S., Le Breton, L., Ke, X., Chen, X., Mayer, M.P. (2017). Isoform-specific phosphorylation in human Hsp90ß affects interaction with clients and the cochaperone Cdc37. J. Mol. Biol. 429:732-752. doi: 10.1016/j.jmb.2017.01.011 (Abstract).

Mogk, A., Bukau, B. (2017). Role of sHsps in organizing cytosolic protein aggregation and disaggregation. Cell Stress Chaperones 22:493-502. doi: 10.1007/s12192-017-0762-4 (Abstract).

Zwirowski, S., Klosowska, A., Obuchowski, I., Nillegoda, N.B., Piróg, A., Zietkiewicz, S., Bukau, B., Mogk, A., Liberek, K. (2017). Hsp70 displaces small heat shock proteins from aggregates to initiate protein refolding. EMBO J. 36:783-796. doi: 10.15252/embj.201593378 (Abstract).

Nillegoda, N.B., Stank, A., Malinverni, D., Alberts, N., Szlachcic, A., Barducci, A., De Los Rios, P., Wade, R.C., Bukau, B. (2017). Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes. Elife doi: 10.7554/eLife.24560 (Abstract).

Garcia, V.M., Nillegoda, N.B., Bukau, B., Morano, K.A. (2017). Substrate binding by the yeast Hsp110 nucleotide exchange factor and molecular chaperone, Sse1, is not obligate for its biological activities. Mol. Biol. Cell pii: mbc.E17-01-0070. doi: 10.1091/mbc.E17-01-0070 (Abstract).

Blank, M., Grummt, I. (2017). The seven faces of SIRT7. Transcription 8:67-74. e1276658. DOI: 10.1080/21541264.2016.1276658 (Abstract).

Blank, M., Chen, S., Poetz, F., Schnölzer, M., Voit, R., Grummt, I. (2017). SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II transcription. Nucl. Acids Res. 45:2675-2686. DOI: 10.1093/nar/gkx053 (Abstract).

Mleczko-Sanecka, K., da Silva, A.R., Call, D., Neves, J., Schmeer, N., Damm, G., Seehofer, D., Muckenthaler, M.U. (2017). Imatinib and spironolactone suppress hepcidin expression. Haematologica. pii: haematol.2016.162917. doi: 10.3324/haematol.2016.162917 (Abstract).

Metzendorf, C., Zeigerer, A., Seifert, S., Sparla, R., Najafi, B., Canonne-Hergaux, F., Zerial, M., Muckenthaler, M.U. (2017). Acute loss of the hepatic endo-lysosomal system in vivo causes compensatory changes in iron homeostasis. Scientific Reports doi:10.1038/s41598-017-02898-4 (Abstract).

Lauinger, L., Li, J., Shostak, A., Cemel, I.A., Ha, N., Zhang, Y., Merkl, P.E., Obermeyer, S., Stankovic-Valentin, N., Schafmeier, T., Wever, W.J., Bowers, A.A., Carter, K.P., Palmer, A.E., Tschochner, H., Melchior, F., Deshaies, R.J., Brunner, M., Diernfellner, A. (2017). Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases. Nat. Chem. Biol. 13:709-714. doi: 10.1038/nchembio.2370 (Abstract).

Yu, J., Grant, O.C., Pett, C., Strahl, S., Woods, R.J., Westerlind, U. (2017). Induction of antibodies directed against branched core O-Mannosyl glycopeptides-selectivity complimentary to the ConA Lectin. Chemistry. 23:3466-3473. doi: 10.1002/chem.201605627 (Abstract).

Caydasi, A.K., Khmelinskii, A., Duenas-Sanchez, R., Kurtulmus, B., Knop, M., Pereira, G. Temporal and compartment-specific signals coordinate mitotic exit with spindle position (2017) Nat. Comm. 8:14129. DOI: 10.1038/ncomms14129 (Abstract).

Muckenthaler, M.U., Rivella, S., Hentze, M.W., Galy, B. A Red Carpet for Iron Metabolism. (2017) Cell 168:344-361. DOI: (Abstract).

Publications from July till December 2016

Ries, H.M., Nussbaum-Krammer, C. (2016). Shape matters: the complex relationship between aggregation and toxicity in protein-misfolding diseases. Essays Biochem. 60:181-190 (Abstract).

Ungelenk, S., Moayed, F., Ho, C.T., Grousl, T., Scharf, A., Mashaghi, A., Tans, S., Mayer, M.P., Mogk, A., Bukau, B. (2016). Small heat shock proteins sequester misfolding proteins in near-native conformation for cellular protection and efficient refolding. Nat Commun. 7:13673. doi: 10.1038/ncomms13673 (Abstract).

Theer, P., Dragneva, D., Knop, M. (2016) πSPIM: high NA high resolution isotropic light-sheet imaging in cell culture dishes. Sci Rep. 6:32880. doi: 10.1038/srep32880 (Abstract).

Kovacs, I., Holzmeister, C., Wirtz, M., Geerlof, A., Fröhlich, T., Römling, G., Kuruthukulangarakoola, G.T., Linster, E., Hell, R., Arnold, G.J., Durner, J., Lindermayr, C. (2016). ROS-mediated inhibition of S-nitrosoglutathione reductase contributes to the activation of anti-oxidative mechanisms. Front. Plant Sci. 7, 1669 (Abstract).

Pfeiffer, A., Janocha, D., Dong, Y., Medzihradszky, A., Schone, S., Daum, G., Suzaki, T., Forner, J., Langenecker, T., Rempel, E., Schmid, M., Wirtz, M., Hell, R., Lohmann, J.U. (2016). Integration of light and metabolic signals for stem cell activation at the shoot apical meristem. elife 5, e17023 (Abstract).

Knieß, R.A., Mayer, M.P. (2016). The oxidation state of the cytoplasmic glutathione redox system does not correlate with replicative lifespan in yeast. Nature Neurosci. doi:10.1038/npjamd.2016.28 (read more).

Zhao, Z., Dammert, M.A., Hoppe, S. Bierhoff, H., Grummt, I. (2016). Heat shock represses rRNA synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning. Nucl. Acids Res. 4:8144-52. doi: 10.1093/nar/gkw496 (Abstract).

Kummer, E., Szlachcic, A., Franke, K.B., Ungelenk, S., Bukau, B., Mogk, A. (2016). Bacterial and Yeast AAA+ Disaggregases ClpB and Hsp104 Operate through Conserved Mechanism Involving Cooperation with Hsp70. J. Mol. Biol. 428:4378-4391. doi: 10.1016/j.jmb.2016.09.003 (Abstract).

Ucar, O., Li, K., Dvornikov, D., Kreutz, C., Timmer, J., Matt, S., Brenner, L., Smedley, C., Travis, M.A., Hofmann, T.G., Klingmüller, U., Kyewski, B. (2016). A Thymic Epithelial Stem Cell Pool Persists throughout Ontogeny and Is Modulated by TGF-ß. Cell Rep. 17: 448-457 (Abstract).

Nilse, L., Avci, D., Heisterkamp, P., Serang, O., Lemberg, M.K., Schilling, O. (2016). Yeast membrane proteomics using leucine metabolic labelling: Bioinformatic data processing and exemplary application to the ER-intramembrane protease Ypf1. Semin. Cell Dev. Biol. 1864, 1363. pii: S1570-9639(16)30138-8. doi: 10.1016/j.bbapap (Abstract).

Lemberg, M.K., Adrain, C. (2016). Inactive Rhomboid Proteins: New Mechanisms with Implications in Health and Disease. Semin. Cell Dev. Biol. 60, 29-37. pii: S1084-9521(16)30184-7; doi: 10.1016/j.semcdb.2016.06.022 (Abstract).

Bartels, M.F., Winterhalter, P.R., Yu, J., Liu, Y., Lommel, M., Möhrlen, F., Hu, H., Feizi, T., Westerlind, U., Ruppert, T., Strahl, S. (2016). Protein O-Mannosylation in the murine brain: Occurrence of mono-O-mannosyl glycans and identification of new substrates. PLoS One. 11:e0166119. doi: 10.1371/journal.pone.0166119 (Abstract).

Carvalho, S., Oliveira, T., Bartels, M.F., Miyoshi, E., Pierce, M., Taniguchi, N., Carneiro, F., Seruca, R., Reis, C.A., Strahl, S., Pinho, S.S. (2016). O-mannosylation and N-glycosylation: two coordinated mechanisms regulating the tumour suppressor functions of E-cadherin in cancer. Oncotarget. 7:65231-65246. doi: 10.18632/ oncotarget.11245 (Abstract).

Publications during the first funding period (July 1, 2012 - June 30, 2016)

Publications from January till June 2016

Shostak, A., Ruppert, B., Ha, N., Bruns, P., Toprak, U.H.; ICGC MMML-Seq Project, Eils, R., Schlesner, M., Diernfellner, A., Brunner, M. (2016). MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation. Nat. Commun. 7:11807. doi: 10.1038/ncomms11807 (Abstract).

Khmelinskii, A., Meurer, M., Ho, C.T., Besenbeck, B., Füller, J., Lemberg, M.K., Bukau, B., Mogk, A., Knop, M. (2016). Incomplete proteasomal degradation of green fluorescent proteins in the context of tandem fluorescent protein timers. Mol. Biol. Cell 27:360-370 doi:10.1091/mbc.E15-07-0525 (Abstract).

Neubert, P., Strahl, S. (2016). Protein O-mannosylation in the early secretory pathway. Curr Opin Cell Biol. 41:100-108. doi: 10.1016/ (Abstract).

Chen, S., Feng, T., Vujic Spasic, M., Altamura, S., Breitkopf-Heinlein, K., Altenöder, J., Weiss, T.S., Dooley, S., Muckenthaler, M.U. (2016). Transforming Growth Factor ß21 (TGF-ß21) Activates Hepcidin mRNA Expression in Hepatocytes. J. Biol. Chem. 291:13160-13174 (Abstract).

Stankovic-Valentin, N., Drzewicka, K., König, C., Schiebel, E., Melchior. F. (2016). Redox regulation of SUMO enzymes is required for ATM activity and survival in oxidative stress. EMBO J. 35:1312-1329 (Abstract).

Huber, F., Bunina, D., Gupta, I., Khmelinskii, A., Meurer, M., Theer, P., Steinmetz, L.M., and Knop, M. (2016). Protein Abundance Control by Non-coding Antisense Transcription. Cell Rep. 15:2625-2636 (Abstract).

Yofe, I., Weill, U., Meurer, M., Chuartzman, S., Zalckvar, E., Goldman, O., Ben-Dor, S., Schütze, C., Wiedemann, N., Knop, M., et al. (2016). One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat. Methods 13:371-378 (Abstract).

Dòka, É., Pader, I., Biró, A., Johansson, K., Cheng, Q., Ballagó, K., Prigge, J.R., Pastor-Flores, D., Dick, T.P., Schmidt, E.E., Arnér, E.S., Nagy, P. (2016) A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems. Sci. Adv. 2:e1500968 (Abstract).

Fujikawa, Y., Roma, L.P., Sobotta, M.C., Rose, A.J., Diaz, M.B., Locatelli, G., Breckwoldt, M.O., Misgeld, T., Kerschensteiner, M., Herzig, S., Muller-Decker, K., Dick, T.P. (2016) Mouse redox histology using genetically encoded probes. Sci. Signal 9:rs1 (Abstract).

Morgan, B., Van Laer, K., Owusu, T.N., Ezerina, D., Pastor-Flores, D., Amponsah, P.S., Tursch, A., Dick, T.P. (2016) Real-time monitoring of basal H2O2 levels with peroxiredoxin-based probes. Nat. Chem. Biol. 12:437-443 (Abstract).

Wunderle, L., Knopf, J.D., Kühnle, N., Morle, A., Hehn, B., Adrain, C., Strisovsky, K., Freeman, M., Lemberg, M.K. (2016) Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGF-alpha. Sci. Rep. 6:27342; doi: 10.1038/srep27342 (Abstract).

Yonashiro, R., Tahara, E.B., Bengtson, M.H., Khokhrina, M., Lorenz, H., Chen, K.C., Kigoshi-Tansho, Y., Savas, J.N., Yates, J.R., Kay, S.A., Craig, E.A., Mogk, A., Bukau, B., Joazeiro, C.A. The Rqc2/Tae2 subunit of the Ribosome-Associated Quality Control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation. (2016) Elife pii: e11794. doi: 10.7554/eLife.11794 (Abstract).

Neubert, P, Halim, A, Zauser, M, Essig, A, Joshi, HJ, Zatorska, E, Larsen, ISB, Loibl, M, Castells-Ballester, J, Aebi, M, Clausen, H, Strahl, S (2016) Mapping the O-mannose Glycoproteome in Saccharomyces cerevisiae. Mol. Cell Proteom. 15:1323-1337, doi: 10.1074/mcp.M115.057505 (Abstract).

Chen, S, Blank, MF, Iyer, A, Huang, B, Wang, L, Grummt, I, Voit. R (2016) SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing. Nat. Commun. 7, 10734, doi: 10.1038/ncomms10734 (Abstract).

Zhao, Z, Dammert, MA, Grummt, I, Bierhoff, H (2016) lncRNA-InducedNucleosomeRepositioningReinforcesTranscriptional Repression of rRNA Genes upon Hypotonic Stress. Cell Rep. 14, 1876-1882, (Abstract).

Matt, S, Thomas G. Hofmann, TG (2016) The DNA damage-induced cell death response: a roadmap to kill cancer cells. Cell. Mol. Life Sci, doi: 10.1007/s00018-016-2130-4 (Abstract).

Hentze, N, Le Breton, L, Wiesner, J, Kempf, G, Mayer, MP (2016) Molecular mechanism of thermosensory function of human heat shock transcription factor Hsf1. eLife pii e11576. doi: 10.7554/eLife.11576 (Abstract).

Vinchi, F, Costa da Silva, M, Ingogli G, Petrillo S, Brinkman N, Zuercher, Cerwenka A, Tolosano E, Muckenthaler, MU (2016) Hemopexin therapy reverts the heme-induced pro-inflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease. Blood 127, 473-486 (Abstract).

Ragni, E., Lommel, M., Moro, M., Crosti, M., Lavazza, C., Parazzi, V., Saredi, S., Strahl, S., Lazzari, L. (2016). Protein O-mannosylation is crucial for human mesencyhmal stem cells fate. Cell Mol Life Sci. 73:445-458. doi: 10.1007/s00018-015-2007-y (Abstract).


Avci, D, Lemberg, M.K. (2015) Clipping or Extracting: Two Ways to Membrane Protein Degradation. Trends Cell Biol. 25, 611-622 (Abstract).

Meissner, C, Lorenz, H, Hehn, B, Lemberg, MK (2015) Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy. Autophagy 11, 1484-1498 (Abstract).

Cherkasov, V, Grousl, T, Theer, P, Vainshtein, Y, Glasser, C, Mongis, C, Kramer, G, Stoecklin, G, Knop, M, Mogk, A et al. (2015) Systemic control of protein synthesis through sequestration of translation and ribosome biogenesis factors during severe heat stress. FEBS Lett. 589, 3654-3664 (Abstract).

Postepska-Igielska, A, Giwojna, A, Gasri-Plotnitsky, L, Schmitt, N, Dold, A, Ginsberg, D, Grummt, I (2015) Khps1 regulates expression of the proto-oncogene SPHK1 via DNA:RNA triplex-mediated changes in chromatin structure. Mol. Cell 60, 626-636 (Abstract).

Caudron-Herger, M, Pankert, T, Seiler, J, Nemeth, A, Voit, R, Grummt, I, Rippe, K (2015) Alu elementcontaining RNAs maintain nucleolar structure and function. EMBO J. 34, 2758-2774 (featured in Assembly of the nucleolus: in need of revision  EMBO J 34, 2731-2732) (Abstract).

Halim, A, Larsen, ISB, Neubert, P, Joshi, HJ, Petersen, BL, Vakhrushev, SY, Strahl, S, Clausen, H (2015) Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast. PNAS 112, 15648-15653 (Abstract).

Voit, R, Seiler, J, Grummt, I (2015) Cooperative action of Cdk1/cyclin B and SIRT1 is required for mitotic repression of rRNA synthesis. PLoS Genet. 11, e1005246 (Abstract).

Conrad, E, Polonio-Vallon, T, Meister, M, Matt, S, Bitomsky, N, Herbel, C, Liebl, M, Greiner, V, Kriznik, B, Schumacher, S, Hofmann, TG (2015) HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism. Cell Death Differ. 23, 110-122 (Abstract).

Reuven, N, Adler, J, Porat, Z, Polonio-Vallon, T, Hofmann, TG, Shaul, Y (2015) The Tyrosine Kinase c-Abl Promotes Homeodomain-interacting Protein Kinase 2 (HIPK2) Accumulation and Activation in Response to DNA Damage. J. Biol. Chem. 290, 16478-16488 (Abstract).

Rattay, K, Claude, J, Rezavandy, E, Matt, S, Hofmann, TG* , Kyewski, B & Derbinski, J (2015) Homeodomain-interacting protein kinase 2, a novel autoimmune regulator interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells. J. Immunol. 194, 921-928 (Abstract).

Matt, S, Hofmann, TG (2015) Crosstalk between p53 modifiers at PML bodies. Mol. Cell. Oncol., advance online publication 27 Jul 2015. DOI: 10.1080/23723556.2015.1074335 (Abstract).

Hollerer, I, Kulozik, AE (2015) The best of 25 years: mRNA 3'end processing. RNA 21, 640-641 (Abstract).

Miller, SB, Ho, CT, Winkler, J, Khokhrina, M, Neuner, A, Mohamed, MY, Guilbride, DL, Richter, K, Lisby, M, Schiebel, E, Mogk, A, Bukau, B (2015) Compartment-specific aggregases direct distinct nuclear and cytoplasmic aggregate deposition. EMBO J. 34, 778-797 (Abstract).

Miller SB, Mogk A, Bukau B (2015) Spatially Organized Aggregation of Misfolded Proteins as Cellular Stress Defense Strategy. J Mol Biol 427, 1564-1574 (Abstract).

Nillegoda NB, Bukau B (2015) Metazoan Hsp70-based protein disaggregases: emergence and mechanisms. Front. Mol. Biosci. 2, 57 (Abstract).

Nillegoda NB, Kirstein J, Szlachcic A, Berynskyy M, Stank A, Stengel F, Arnsburg K, Gao X, Scior A, Aebersold R, Guilbride DL, Wade RC, Morimoto RI, Mayer MP, Bukau B (2015) Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation. Nature 524, 247-251 (Abstract).

Suresh HG, da Silveira Dos Santos AX, Kukulski W, Tyedmers J, Riezman H, Bukau B, Mogk A (2015) Prolonged starvation drives reversible sequestration of lipid biosynthetic enzymes and organelle reorganization in Saccharomyces cerevisiae. Mol. Biol. Cell 26, 1601-1615 (Abstract).

Hauer, C., Curk, T., Anders, S., Schwarzl, T., Alleaume, AM., Sieber, J., Hollerer, I., Bhuvanagiri, M., Huber, W., Hentze, MW., Kulozik, AE. (2015). Improved binding site assignment by high-resolution mapping of RNA-protein interactions using iCLIP. Nat. Commun. 6, 7921. doi: 10.1038/ncomms8921 (Abstract).

Cherkasov, V, Grousl, T, Theer, P, Vainshtein, Y, Glasser, C, Mongis, C, Kramer, G, Stoecklin, G, Knop, M, Mogk, A et al. (2015) Systemic control of protein synthesis through sequestration of translation and ribosome biogenesis factors during severe heat stress. FEBS Lett. 589, 3654-3664 (Abstract).

Mayer MP, Le Breton L (2015) Hsp90: Breaking the Symmetry. Mol. Cell 58, 8-20 (Abstract).

Dinh, TV, Bienvenut, WV, Linster, E, Feldman-Salit, A, Jung, VA, Meinnel, T, Hell, R, Giglione, C, Wirtz, M (2015) Molecular identification and functional characterization of the first Nalpha-acetyltransferase in plastids by global acetylome profiling. Proteomics 15, 2426-2435 (Abstract).

Linster, E., Stephan, I., Bienvenut, W.V., Maple-Grodem, J., Myklebust, L.M., Huber, M., Reichelt, M., Sticht, C., Geir Moller, S., Meinnel, T., Arnesen, T., Giglione, C., Hell, R., and Wirtz, M. (2015) Downregulation of Nterminal acetylation triggers ABA-mediated drought responses in Arabidopsis. Nat. Commun. 6, 7640 (Abstract).

Xu, F., Huang, Y., Li, L., Gannon, P., Linster, E., Huber, M., Kapos, P., Bienvenut, W., Polevoda, B., Meinnel, T., Hell, R., Giglione, C., Zhang, Y., Wirtz, M., Chen, S., and Li, X. (2015) Two N-terminal acetyltransferases antagonistically regulate the stability of a nod-like receptor in Arabidopsis. Plant Cell 27, 1547-1562 (Abstract).

Sobotta, MC, Liou, W, Stocker, S, Talwar, D, Oehler, M, Ruppert, T, Scharf, AN, Dick, TP (2015) Peroxiredoxin-2 and STAT3 form a redox relay for H2 O2 signaling. Nat. Chem. Biol. 11, 64-70 (Abstract).

Peralta, D, Bronowska, AK, Morgan, B, Doka, E, Van Laer, K, Nagy, P, Grater, F, Dick, TP (2015) A proton relay enhances H2 O2 sensitivity of GAPDH to facilitate metabolic adaptation. Nat. Chem. Biol. 11, 156-163 (Abstract).

Greiner R, Dick TP (2015) Real-time assays for monitoring the influence of sulfide and sulfane sulfur species on protein thiol redox states. Meth. Enzymol. 555, 57-77 (Abstract).

Guida, C, Altamura, S, Klein, FA, Galy, B, Boutros, M, Ulmer, AJ, Hentze, MW, Muckenthaler, MU (2015) A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia. Blood 125, 2265-2275 (Abstract).

Babu, RB, Muckenthaler MU (2015) miR-20a regulates expression of the iron exporter ferroportin in lung cancer. J. Mol. Med. PMID:26560875 (Abstract).

Cesbron, F, Oehler, M, Ha, N, Sancar, G, Brunner, M (2015) Transcriptional refractoriness is dependent on core promoter architecture. Nat. Commun. 6, 6753. doi: 10.1038/ncomms7753 (Abstract).

Sancar, C, Ha, N, Yilmaz, R, Tesorero, R, Fischer, T, Brunner, M & Sancar, G (2015) Combinatorial control of light induced chromatin remodeling and gene activation in Neurospora. PLoS Genet. 11, e1005105. doi:10.1371/journal.pgen.1005105 (Abstract).

Sancar, C, Sancar, G, Ha, N, Cesbron, F, Brunner M (2015) Dawn- and dusk-phased circadian transcription rhythms coordinate anabolic and catabolic functions in Neurospora. BMC Biol. 13, 17 (Abstract).


Avci, D, Fuchs, S, Schrul, B, Fukumori, A, Breker, M, Frumkin, I, Chen, C, Biniossek, ML, Kremmer, E, Schilling, O, Steiner, H, Schuldiner, M, Lemberg MK.(2014) The yeast ER-intramembrane protease Ypf1 refines nutrient sensing by regulating transporter abundance. Mol. Cell. 56, 630-640 (Abstract).

Chen, C, Malchus, NS, Hehn, B, Stelzer, W, Avci, D, Langosch, D, Lemberg, MK (2014) Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u. EMBO J. 33, 2492-2506 (Abstract).

Loibl, M, Wunderle, L, Hutzler, J, Schulz, BL, Aebi, M, Strahl, S (2014) Protein O-mannosyltransferases associate with the translocon to modify translocating polypeptide chains. J. Biol. Chem. 289, 8599-611 (Abstract).

Huber, F, Meurer, M, Bunina, D, Kats, I, Maeder, CI. Stefl, M, Mongis, C, Knop, M (2014). PCR Duplication: A One-Step Cloning-Free Method to Generate Duplicated Chromosomal Loci and Interference-Free Expression Reporters in Yeast. PLoS ONE, e114590 (Abstract).

Khmelinskii, A, Blaszczak, E, Pantazopoulou, M, Fischer, B, Omnus, DJ, Le Dez, G, Brossard, A, Gunnarsson, A, Barry, JD, Meurer, M, Kirrmaier, D, Boone, C, Rabout, G, Ljungdahl, P, Knop, M (2014) Protein quality control at the inner nuclear membrane. Nature 516, 410-413 (Abstract).

Meitinger, F, Khmelinskii, A, Morlot, S, Kurtulmus, B, Palani, S, Andres-Pons, A, Hub, B, Knop, M, Charvin, G, Pereira, G. (2014) A memory system of negative polarity cues prevents replicative aging. Cell 159, 1056-1069 (Abstract).

Theer, P, Mongis, C, Knop, M (2014) PSFj: know your fluorescence microscope. Nat. Meth. 11, 981-982 (Abstract).

Kinkhabwala, A, Khmelinskii, A, Knop, M (2014) Analytical model for macromolecular partitioning during yeast cell division. Bmc Biophysics 7, 10 (Abstract).

Khmelinskii, A, Knop, M (2014) Analysis of protein dynamics with tandem fluorescent protein timers. Meth. Mol. Biol. 1174, 195-210 (Abstract).

Knop, M, Edgar, B (2014) Tracking protein turnover and degradation by microscopy: photo-switchable Versus time-encoded fluorescent proteins. Open Biol. 4, e140002 (Abstract).

Arab, K, Park, YJ, Lindroth, AM, Schäfer, A, Oakes, C, Weichenhan, D, Lukanova, A, Lundin, A, Risch, A, Meister, M, Dienemann H, Dyckhoff, G, Herold-Mende, C, Grummt, I, Niehrs, C, Plass, C (2014) Long noncoding RNA, TARID, directs demethylation and activation of the tumor suppressor TCF21 via GADD45A. Mol. Cell 55, 604-614 (Abstract).

Bierhoff, H, Dammert, M, Brocks, D, Dambacher, S, Schotta, G, Grummt, I (2014) Quiescence-induced LncRNAs trigger H4K20 trimethylation and transcriptional silencing. Mol. Cell 54, 675-682 (Abstract).

Klermund, J, Bender, K, Luke B (2014) High nutrient levels and TORC1 activity reduce cell viability following prolonged telomere dysfunction and cell cycle arrest. Cell Rep. 9, 324-335 (Abstract).

Maicher, A, Lockhart, A, Luke B. (2014) Breaking new ground: digging into TERRA function. Biochim. Biophys. Acta 1839, 387-394 (Abstract).

Balk, B, Dees, M, Bender, K, Luke B (2014) The differential processing of telomeres in response to increased telomeric transcription and RNA-DNA hybrid accumulation. RNA Biol. 11, 95-100 (Abstract).

Abu-Odeh, M, Salah, Z, Herbel, C, Hofmann, TG & Aqeilan, RI (2014) WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response. PNAS 111, E4716-4725 (Abstract).

Polonio-Vallon, T, Kruger, D, Hofmann, TG (2014) ShaPINg Cell Fate Upon DNA Damage: Role of Pin1 Isomerase in DNA Damage-Induced Cell Death and Repair. Frontiers in Oncology 4, 148 (Abstract).

Agircan, FG, Schiebel, E (2014) Sensors at centrosomes reveal determinants of local separase activity. PLoS Genet. 10, e1004672, doi:10.1371/journal.pgen.1004672 (Abstract).

Hollerer, I, Grund, K, Hentze, MW, Kulozik, AE (2014) mRNA 3-end processing: A tale of the tail reaches the clinic. EMBO Mol Med 6, 16-26 (Abstract).

Schott, J, Reitter, S, Philipp, J, Haneke, K, Schafer, H, Stoecklin, G (2014) Translational regulation of specific mRNAs controls feedback inhibition and survival during macrophage activation. PLoS Genet. 10, e1004368 (Abstract).

Leppek, K, Stoecklin, G (2014) An optimized streptavidin-binding RNA aptamer for purification of ribonucleoprotein complexes identifies novel ARE-binding proteins. Nucl. Acids Res. 42, e13 (Abstract).

Mogk A, Bukau B (2014) Mitochondria thether protein trash to rejuvenate cellular environments. Cell 159, 471-472 (Abstract).

Schwertassek U, Haque A, Krishnan N, Greiner R, Weingarten L, Dick TP, Tonks NK (2014) Reactivation of oxidized PTP1B and PTEN by thioredoxin 1. FEBS J. 281, 3545-3558 (Abstract).

Ezerina D, Morgan B, Dick TP (2014) Imaging dynamic redox processes with genetically encoded probes. J. Mol. Cell Cardiol. 73, 43-49 (Abstract).

Breckwoldt MO, Pfister FM, Bradley PM, Marinkovic P, Williams PR, Brill MS, Plomer B, Schmalz A, St Clair, DK, Naumann R, Griesbeck O, Schwarzlander M, Godinho L, Bareyre FM, Dick TP, Kerschensteiner M, Misgeld T (2014) Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo. Nat. Med. 20, 555-560 (Abstract).

Elbaz-Alon, Y, Morgan, B, Clancy, A, Amoako, TN, Zalckvar, E, Dick, TP, Schwappach, B, Schuldiner, M (2014) The yeast oligopeptide transporter Opt2 is localized to peroxisomes and affects glutathione redox homeostasis. FEMS Yeast Res. 14, 1055-1067 (Abstract).

Sancar, G, Brunner, M (2014) Circadian clocks and energy metabolism. Cell Mol Life Sci 71, 2667-2680 (Abstract).

Mleczko-Sanecka K, Roche F, da Silva AR, Call D, D'Alessio F, Ragab A, Lapinski PE, Ummanni R, Korf U, Oakes C, Damm G, D'Alessandro LA, Klingmuller U, King PD, Boutros M, Hentze MW, Muckenthaler MU (2014) Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient- dependent mTOR signaling. Blood 123, 1574-1578 (Abstract).


Bergbold, N, Lemberg, MK (2013) Emerging role of rhomboid family proteins in mammalian biology and disease. Biochim. Biophys. Acta. 1828, 2840-2848 (Abstract).

Lemberg, MK (2013) Sampling the membrane: Function of rhomboid-family proteins. Trends Cell Biol. 23, 210-217 (Abstract).

Loibl, M, Strahl, S (2013) Protein O-mannosylation: what we have learned from baker's yeast. Biochim. Biophys. Acta 1833, 2438 (Abstract).

Chen, S, Santiago-Reichelt, M, Seiler, J, Felbel, K, Grummt, I, Voit, R (2013) Repression of RNA polymerase I transcription upon stress is caused by inhibition of RNA-dependent deacetylation of PAF53 by SIRT7. Mol. Cell 52, 303-313 (Abstract) (featured in AC/D(eA)C rocks the polymerases  Mol. Cell 52, 287-288).

Balk, B, Maicher, A, Klermund, J, Luke-Glaser, S., Dees, M, Bender, K, Luke, B (2013) Telomeric RNA-DNA hybrids affect telomere length dynamics and senescence. Nat. Struct. Mol. Biol. 20, 1199-1205 (Abstract).

Bitomsky, N, Conrad, E, Moritz, C, Polonio-Vallon, T, Sombroek, D, Schultheiss, K, Glas, C, Greiner, V, Herbel, C, Mantovani, F, del Sal, G, Peri, F, Hofmann, TG (2013) Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death. PNAS 110, E4203-4212 (Abstract).

Hofmann, TG, Glas, C, Bitomsky, N (2013) HIPK2: A tumour suppressor that controls DNA damageinduced cell fate and cytokinesis. BioEssays 35, 55-64 (Abstract).

Leppek, K, Schott, J, Reitter, S, Poetz, F, Hammond, MC, Stoecklin, G (2013) Roquin Promotes Constitutive mRNA Decay via a Conserved Class of Stem-Loop Recognition Motifs. Cell 153, 869-881 (Abstract).

Stoecklin, G, Bukau, B (2013) Telling right from wrong in life - cellular quality control. Nat. Rev. Mol. Cell Biol. 14, 613-615 (Abstract).

Stoecklin, G, Kedersha, N (2013) Relationship of GW/P-bodies with stress granules. Adv. Exp. Med. Biol. 768,197-211 (Abstract).

Cherkasov V, Hofmann S, Druffel-Augustin S, Mogk A, Tyedmers J, Stoecklin G, Bukau B (2013) Coordination of translational control and protein homeostasis during severe heat stress. Curr. Biol. 23, 2452-2462 (Abstract).

Mayer MP (2013) Hsp70 chaperone dynamics and molecular mechanism. Trends Biochem. Sci. 38, 507-514 (Abstract).

Flotho, F, Melchior, F (2013) SUMOylation - a regulatory protein modification in health and disease. Annu. Rev. Biochem. 82, 357-385 (Abstract).

Publications from July till December 2012

Ruggieri, A, Dazert, E, Metz, P, Hofmann, S, Bergeest, JP, Mazur, J, Bankhead, P, Hiet, MS, Kallis, S, Alvisi, G, Samuel CE, Lohmann V, Kaderali L, Rohr K, Frese M, Stoecklin G, Bartenschlager R (2012) Dynamic oscillation of translation and stress granule formation mark the cellular response to virus infection. Cell Host Microbe 12, 71-85 (Abstract).

Hofmann, S, Cherkasova, V, Bankhead, P, Bukau, B, Stoecklin, G (2012) Translation suppression promotes stress granule formation and cell survival in response to cold shock. Mol. Biol. Cell 23, 3786-3800 (Abstract).