Ruprecht-Karls-Universitšt Heidelberg

Open Positions

Position for a Diploma thesis / Masters thesis

Please inquire! We have always interesting research questions out of the Hsp70 and Hsp90 field that could be answered within the time frame of a master thesis.
Interested students should write to

Selected publications of the Mayer Group:

Mayer, MP. Hsp70 chaperone dynamics and molecular mechanism. Trends Biochem Sci (2013) 38, 507-514..
Kityk R, Kopp J, Sinning I, Mayer MP. Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones. Mol Cell (2012) pii: S1097-2765(12)00823-4.
Mayer MP. Gymnastics of molecular chaperones. Mol. Cell. (2010) 39, 321-33.
Stankiewicz M, Nikolay R, Rybin V, Mayer MP. CHIP participates in protein triage decisions by preferentially ubiquitinating Hsp70-bound substrates. FEBS J. (2010) 277, 3353-3367.
Graf C, Stankiewicz M, Nikolay R, Mayer MP. Insights into the Conformational Dynamics of the E3 Ubiquitin Ligase CHIP in Complex with Chaperones and E2 Enzymes. Biochemistry. (2010) 49, 2121-2129.
Graf C, Stankiewicz M, Kramer G, Mayer MP. Spatially and kinetically resolved changes in the conformational dynamics of the Hsp90 chaperone machine. EMBO J. (2009) 28, 602-613.
Rodriguez F, Arsene-Ploetze F, Rist W, Rüdiger S, Schneider-Mergener J, Mayer MP, Bukau B. Molecular basis for regulation of the heat shock transcription factor sigma32 by the DnaK and DnaJ chaperones. Mol. Cell. (2008) 32, 347-358.
Rist, W., Graf, C., Bukau, B., and Mayer, MP. Amide hydrogen exchange reveals conformational changes in Hsp70 chaperones important for allosteric regulation. J Biol Chem. (2006) 281, 16493-16501.

Vogel, M., Bukau, B., Mayer, MP. Allosteric regulation of Hsp70 chaperones by a proline switch. Mol. Cell. (2006). 21, 359-367.

Robert and Chung-Tien doing an experiment