Ruprecht-Karls-Universität Heidelberg

Publications by the Dobberstein Lab

Search pubmed for publications by Bernhard Dobberstein

Vilardi, F., Lorenz, H. and Dobberstein, B. (2011). WRB is the receptor for TRC40/Asna1 mediated ER membrane insertion of tail-anchored proteins. J. Cell Science 124:1301-1307.

Pool, M. and Dobberstein, B. (2011). Cotranslational translocation of proteins into microsomes: Methods. In: Encyclopedia of Life Sciences (ELS). John Wiley & Sons Ltd.

Schrul, B., Kapp, K. Sinning, I. and Dobberstein, B. (2010). Signal peptide peptidase (SPP) assembles with substrates and misfolded membrane proteins into distinct oligomeric complexes. Biochem. J. 427:523-534 (Open access:

Bozkurt, G., Wild, K., Amlacher, S., Hurt, E., Dobberstein, B. and Sinning, I. (2010). The structure of Get4 reveals an alpha-solenoid fold adapted for multiple interactions in tail-anchored protein biogenesis. FEBS Lett. 584(8):1509-14.

Kilic, A., Klose, S., Dobberstein, B., Knust, E. and Kapp, K. (2010). The Drosophila Crumbs signal peptide is unusually long and is a substrate for signal peptide peptidase. Eur. J. Cell Biol. 89(6):449-61.

Favaloro, V., Vilardi, F., Schlecht, R., Mayer, M.P. and Dobberstein, B. (2010). Asna1/TRC40-mediated membrane insertion of tail-anchored proteins. J. Cell Science 123(Pt 9):1522-30.

Bozkurt, G., Stjepanovic, G., Vilardi. F., Amlacher, S., Wild, K., Bange, G., Favaloro, V., Rippe, K., Hurt, E., Dobberstein, B. and Sinning, I. (2009). Structural insights into tail-anchored protein binding and membrane insertion by Get3. PNAS 106:21131-21136.

Kelkar, A. and Dobberstein, B. (2009). Sec61beta, a subunit of the Sec61 protein translocation channel at the Endoplasmic Reticulum, is involved in the transport of Gurken to the plasma membrane. BMC Cell Biology 10:11 (doi: 10.1186/1471-2121-10-11).

Kapp, K., Schrempf, S., Lemberg. M.K. and Dobberstein, B. (2009). Post-targeting functions of signal peptides. In: Protein Transport into the Endoplasmic Reticulum, Ed. R. Zimmermann, Landes Bioscience (Open access:

Dultz E., Hildenbeutel M., Martoglio B., Hochman J., Dobberstein B. and Kapp K. (2008). The signal peptide of the mouse mammary tumor virus rem protein is released from the ER membrane and accumulates in nucleoli. J Biol Chem. 283: 9966-9976.

Favaloro, V., Spasic, M., Schwappach, B. and Dobberstein, B. (2008). Distinct targeting pathways for the membrane insertion of tail-anchored (TA) proteins. J. Cell Science 121:1832-1840.

Schrempf, S., Froeschke, M., Giroglou, T., von Laer, D. and Dobberstein, B. (2007). Signal Peptide Requirements for Lymphocytic Choriomeningitis Virus Glycoprotein C Maturation and Virus Infectivity. Journal of Virology 81: 12515-12524.

Roemisch, K., Miller, F.W., Dobberstein, B. and High, S. (2006). Human autoantibodies against the 54 kDa protein of the signal recognition particle block function at multiple stages. Arthritis Research & Therapy 8:R39.

1994 - 2005

Dobberstein, B. and Sinning, I. (2004). Surprising news from the PCC. Science 303:320-322.

Terzi, L., Pool, M.R., Dobberstein, B. and Strub, K. (2004). The signal recognition particle Alu domain occupies a defined site at the ribosomal subunit interface upon signal sequence recognition, Biochem. 43:107-117.

Froeschke, M., Basler, M., Groettrup, M. and Dobberstein, B. (2003). Long-lived signal peptide of lymphocytic choriomeningitis virus glycoprotein pGP-C. J. Biol. Chem. 278:41914-41920.

Pool, M.R., Stumm, J. Fulga, T.A., Sinning, I. and Dobberstein, B. (2002). Distinct modes of signal recognition particle interaction with the ribosome. Science 297:1345-1348 .

Hoelscher, C., Bach, U.C. and Dobberstein, B. (2001). Prion protein contains a second endoplasmic reticulum targeting signal sequence located at its C-terminus. J. Biol. Chem. 276:13388-13394.

Fulga, T.A., Sinning, I., Dobberstein, B. and Pool, M.R. (2001). SP-beta coordinates signal sequence release from SRP with ribosome binding to the translocon. EMBO J. 20:2338-2347.

Gruss, O.J., Feick, P., Frank, R. and Dobberstein, B. (1999). Phosphorylation of components of the ER translocation site. Eur. J. Biochem. 260:785-793.

Schroeder, K., Martoglio, B., Hofmann, M., Hoelscher, C., Hartmann, E., Prehn, S., Rapoport, T.A. and Dobberstein, B. (1999). Control of glycosylation of MHC class II-associated invariant chain by translocon-associated RAMP4. EMBO J. 18:4804-4815.

Bacher, G., Pool, M. and Dobberstein, B. (1999). The ribosome regulates the GTPase of the beta-subunit of the signal recognition particle receptor. J. Cell Biol. 146:723-730.

Wang, L. and Dobberstein, B. (1999). Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum. FEBS Lett. 457:316-322.

Hofmann, M.W., Hoening, S., Rodionov, D., Dobberstein, B., von Figura, K. and Bakke, O. (1999). The leucine-based sorting motifs in the cytoplasmic domain of the invariant chain are recognized by the clathrin adaptors AP1 and AP2 and their medium chains. J. Biol. Chem. 273:36153-36158.

Martoglio, B. and Dobberstein, B. (1998). Signal sequences - more than just greasy peptides. TiCB 8,410-415.

Martoglio, B., Graf, R. and Dobberstein, B. (1997). Signal peptide fragments of preprolactin and HIV-1 p-gp 160 interact with calmodulin. EMBO J. 16, 6636-6645.

Martoglio, B. and Dobberstein, B. (1996). Snapshots of membrane-translocating proteins. TiCB 6, 142-147.

Luetcke, H. (1995). Signal recognition particle (SRP), a ubiquitous initiator of protein translocation. Eur. J. Biochem. 228, 531-550.

Hauser, S., Bacher, G., Dobberstein, B., and Luetcke, H. (1995). A complex of the signal sequence binding protein and the SRP RNA promotes translocation of nascent proteins. EMBO J. 14, 5485-5493.

Jadot, M., Hofmann, M. W., Graf, R., Quader, H., and Martoglio, B. (1995). Protein insertion into the endoplasmic reticulum of permeabilized cells. FEBS Lett. 371, 145-148.

Lyko, F., Martoglio, B., Jungnickel, B., Rapoport, T. A., and Dobberstein, B. (1995). Signal sequence processing in rough microsomes. J. Biol. Chem. 270, 19873-19878.

Martoglio, B., Hofmann, M., Brunner, J., and Dobberstein, B. (1995). The protein-conducting channel in the membrane of the endoplasmic reticulum is open laterally toward the lipid bilayer. Cell 81, 207-214.

Vogt, A. B., Stern, L.J., Amshoff, C., Dobberstein, B., Haemmerling, G.J., and Kropshofer, H. (1995). Interference of distinct invariant chain regions with superantigen contact area and antigenic peptide binding groove of HLA-DR. J. Immunol. 155, 4757-4765.

Lentzen, G., Dobberstein, B. and Wintermeyer, W. (1994). Formation of SRP-like particle induces a conformational change in E. coli 4.55 RNA. FEBS Letters, 348: 233-238.

Luirink, J. and Dobberstein, B. (1994). Micro Review. Mammalian and Escherichia coli signal recognition particles. Mol. Microbiol. 11(1): 9-13.

Luirink, J., ten Hagen-Jongman, C.M., van der Weijden, C.C., Oudega, B., High, S., Dobberstein, B. and Kusters, R. (1994). An alternative protein targeting pathway in Escherichia coli: studies on the role of FtsY. EMBO J. 13(10): 2289-2296.

Tulp, A., Verwoerd, D., Dobberstein, B., Ploegh, H.L. and Pieters, J. (1994). Isolation and characterization of the intracellular MHC class II compartment. Nature 369: 120-126.

Dobberstein, B. 1994. Protein transport. On the beaten pathway. Nature 367: 599-600.

Publications by members of the lab

Zivná, M., Hůlková, H., Matignon, M., Hodanová, K., Vylet'al, P., Kalbácová, M., Baresová, V., Sikora, J., Blazková, H., Zivný, J., Ivánek, R., Stránecký, V., Sovová, J., Claes, K., Lerut, E., Fryns, J.P., Hart, P.S., Hart, T.C., Adams, J.N., Pawtowski, A., Clemessy, M., Gasc, J.M., Gübler, M.C., Antignac, C., Elleder, M., Kapp, K., Grimbert, P., Bleyer, A.J., Kmoch, S.  (2009). Dominant renin gene mutations associated with early-onset hyperuricemia, anemia, and chronic kidney failure. Am. J. Hum. Genet. 85(2):204-13.

Lundin, C., Kaell, L., Kreher, S.A., Kapp, K., Sonnhammer, E.L. Carlson, J.R., von Heijne, G. and Nilsson, I. (2007). Membrane topology of the Drosophila OR83b odorant receptor. FEBS Lett. 581: 5601-5604.

Freigang, S., Eschli, B., Harris, N., Geuking, M., Quirin, K., Schrempf, S., Zellweger, R., Weber, J., Hengartner, H. and Zinkernagel, R.M. (2007). A lymphocytic choriomeningitis virus glycoprotein variant that is retained in the endoplasmic reticulum efficiently cross-primes CD8+ T cell responses. PNAS 104: 13426-13431.

Bernhard Dobberstein's list of publications: 1974-1993 (Download PDF)

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