Ruprecht-Karls-Universität Heidelberg

Publications by the Pfeffer Lab

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Original Research Papers

Delarue, M.*, Brittingham, G.P.*, Pfeffer, S.*, Surovtsev, I.V. , Pinglay, S., Kennedy, K.J., Schaffer, M., Gutierrez, J.I., Sang, D., Poterewicz, G., Chung, J.K., Plitzko, J.M., Groves, J.T., Jacobs-Wagner, C., Engel, B.D., Holt, L.J., 2018. mTORC1 controls phase separation and the biophysical properties of the cytoplasm by tuning crowding. Cell, in press

Braunger, K.*, Pfeffer, S.*, Shrimal, S., Gilmore, R., Berninghausen, O., Mandon, E.C., Becker, T., Förster, F., Beckmann, R., 2018. Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum. Science 360, 215-219.

Pfeffer, S., Dudek, J., Schaffer, M., Ng, B., Albert, S., Plitzko, J.M., Baumeister, W., Zimmermann, R., Freeze, H.H., Engel, B.D., Förster, F., 2017. Dissecting the molecular organization of the translocon-associated protein complex. Nat Commun 8, 14516.

Pfeffer, S., Burbaum, L., Unverdorben, P., Pech, M., Chen, Y., Zimmermann, R., Beckmann, R., Förster, F., 2015. Structure of the native Sec61 protein-conducting channel. Nat Commun 6, 8403.

Pfeffer, S.*, Woellhaf, M.W.*, Herrmann, J.M., Förster, F., 2015. Organization of the mitochondrial translation machinery studied in situ by cryoelectron tomography. Nat Commun 6, 6019.

Pfeffer, S.*, Dudek, J.*, Gogala, M., Schorr, S., Linxweiler, J., Lang, S., Becker, T., Beckmann, R., Zimmermann, R., Förster, F., 2014. Structure of the mammalian oligosaccharyl-transferase complex in the native ER protein translocon. Nat Commun 5, 3072.

Pfeffer, S., Brandt, F., Hrabe, T., Lang, S., Eibauer, M., Zimmermann, R., Förster, F., 2012. Structure and 3D Arrangement of Endoplasmic Reticulum Membrane-Associated Ribosomes. Structure 20, 1508-1518.

Englmeier, R., Pfeffer, S., and Förster, F., 2017. Structure of the Human Mitochondrial Ribosome Studied In Situ by Cryoelectron Tomography. Structure 25, 1574-1581.

Khoshouei, M.*, Pfeffer, S.*, Baumeister, W., Förster, F., Danev, R., 2016. Subtomogram analysis using the Volta phase plate. J. Struct. Biol. 197, 94-101.

Mahamid, J., Pfeffer, S., Schaffer, M., Villa, E., Danev, R., Cuellar, L.K., Förster, F., Hyman, A.A., Plitzko, J.M., Baumeister, W., 2016. Visualizing the molecular sociology at the HeLa cell nuclear periphery. Science 351, 969-972.

Chen, Y., Pfeffer, S., Hrabe, T., Schuller, J.M., Förster, F., 2013. Fast and Accurate Reference-Free Alignment of Subtomograms. J. Struct. Biol. 182, 235-245.

Chen, Y., Pfeffer, S., Fernandez, J.J., Sorzano, C.O., Förster, F., 2014. Autofocused 3D classification of cryoelectron subtomograms. Structure 22, 1528-1537.

Hrabe, T., Chen, Y., Pfeffer, S., Cuellar, L.K., Mangold, A.V., Förster, F., 2012. PyTom: a python-based toolbox for localization of macromolecules in cryo-electron tomograms and subtomogram analysis. J. Struct. Biol. 178, 177-188.


Review Articles

Pfeffer, S., Dudek, J., Zimmermann, R., Förster, F., 2016. Organization of the native ribosome-translocon complex at the mammalian endoplasmic reticulum membrane. Biochim Biophys Acta 10, 2122-2129.

Pfeffer, S., Förster, F., 2016. Sec61: A static framework for membrane-protein insertion. Channels (Austin) 10, 167-169.

Dudek, J., Pfeffer, S., Lee, P.H., Jung, M., Cavalie, A., Helms, V., Förster, F., Zimmermann, R., 2014. Protein Transport into the Human Endoplasmic Reticulum. J. Mol. Biol. 427, 1159-1175.

Lang, S., Pfeffer, S., Lee, P.H., Cavalié, A., Helms, V., Förster, F., Zimmermann, R., 2017. An Update on Sec61 Channel Functions, Mechanisms, and Related Diseases. Front Physiol. 8, 887.

* = equal contribution


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