Research articles

Kücükköse, C., Taskin, A.A., Marada, A., Brummer, T., Dennerlein, S., and Vögtle, F.N. (2021). Functional coupling of presequence processing and degradation in human mitochondria. FEBS J., 288, 600-613.

Tosal-Castano, S., Peselj, C., Kohler, V., Habernig, L., Berglund, L.L., Ebrahimi, M., Vögtle, F.N., Höög, J., Andréasson, C., and Büttner, S. (2021). Snd3 controls nucleus-vacuole junctions in response to glucose signaling. Cell Rep. 34, 108637.

Poveda-Huertes, D., Matic, S., Marada, A., Habernig, L., Licheva, M., Myketin, L., Gilsbach, R., Tosal-Castano, S., Papinski, D., Mulica, P., Kretz, O., Kücükköse, C., Taskin, A.A., Hein, L., Kraft. C., Büttner, S., Meisinger, C., and Vögtle, F.N. (2020). An early mtUPR: Redistribution of the nuclear transcription factor Rox1 into mitochondria protects against intramitochondrial proteotoxic aggregates. Mol. Cell 77, 180-188.

Makepeace, K.A.T., Mohammed, Y., Rudashevskaya, E.L., Petrotchenko, E.V., Vögtle, F.N., Meisinger, C., Sickmann, A., and Borchers, C.H. (2020). Improving Identification of In-organello Protein-Protein Interactions Using an Affinity-enrichable, Isotopically Coded, and Mass Spectrometry-cleavable Chemical Crosslinker. Mol. Cell. Proteomics 19, 624-639.

Niemi, N.M., Wilson, G.M., Overmyer, K.A., Vögtle, F.N., Myketin, L., Lohman, D.C., Schueler, K.L., Attie, A.D., Meisinger, C., Coon, J.J., and Pagliarini, D.J. (2019). Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis. Nat. Commun. 10, 3197.

Heublein, M., Ndi, M., Calvo, C.V., Vögtle, F.N., and Ott, M. (2019). Alternative Translation Initiation at a UUG Codon Gives Rise to Two Functional Variants of the Mitochondrial Protein Kgd4. J. Mol. Biol. 431, 1460-1467.

Vögtle, F.N.#,*, Brändl, B.*, Larson, A.*, Pendziwiat, M.*, Friederich, M.W.*, White, S.M., Basinger, A., Kücükköse, C., Muhle, H., Jähn, J.A., Keminer, O., Helbig, K.L., Delto, C.F., Myketin, L., Mossmann, D., Burger, N., Miyake, N., Burnett, A., van Baalen, A., Lovell, M.A., Matsumoto, N., Walsh, M., Yu, H.C., Shinde, D.N., Stephani, U., Van Hove, J.L.K., Müller, F.J., Helbig, I.# (2018). Mutations in PMPCB Encoding the Catalytic Subunit of the Mitochondrial Presequence Protease Cause Neurodegeneration in Early Childhood. Am. J. Hum. Genet. 102, 557-573.
#corresponding, * equal contribution

Aufschnaiter, A., Kohler, V., Walter, C., Tosal-Castano, S., Habernig, L., Wolinski, H., Keller, W., Vögtle, F.N., and Büttner, S. (2018). The Enzymatic Core of the Parkinson's Disease-Associated Protein LRRK2 Impairs Mitochondrial Biogenesis in Aging Yeast. Front. Mol. Neurosci. 11, 205.

Kravic, B., Harbauer, A.B., Romanello, V., Simeone, L., Vögtle, F.N., Kaiser, T., Straubinger, M., Huraskin, D., Böttcher, M., Cerqua, C., Martin, E.D., Poveda-Huertes, D., Buttgereit, A., Rabalski, A.J., Heuss, D., Rudolf, R., Friedrich, O., Litchfield, D., Marber, M., Salviati, L., Mougiakakos, D., Neuhuber, W., Sandri, M., Meisinger, C., and Hashemolhosseini, S. (2018). In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy. Autophagy 14, 311-335.

Vögtle, F.N.*, Burkhart, J.M.*, Gonczarowska-Jorge, H., Kücükköse, C., Taskin, A.A., Kopczynski, D., Ahrends, R., Mossmann, D., Sickmann, A., Zahedi, R.P., and Meisinger, C. (2017). Landscape of submitochondrial protein distribution. Nat. Commun. 8, 290.
*equal contribution

Krüger, V., Becker, T., Becker, L., Montilla-Martinez, M., Ellenrieder, L., Vögtle, F.N., Meyer, H.E., Ryan, M.T., Wiedemann, N., Warscheid, B., Pfanner, N., Wagner, R., and Meisinger, C. (2017). Identification of new channels by systematic analysis of the mitochondrial outer membrane. J. Cell Biol. 216, 3485-3495.

Taskin, A.A., Kücükköse, C., Burger, N., Mossmann, D., Meisinger, C., and Vögtle, F.N. (2017). The novel mitochondrial matrix protease Ste23 is required for efficient presequence degradation and processing. Mol. Biol. Cell 28, 997-1002.

Eldomery, M.K.*, Akdemir, Z.C.*, Vögtle, F.N.*, Charng, W.L., Mulica, P., Rosenfeld, J.A., Gambin, T., Gu, S., Burrage, L.C., Al Shamsi, A., Penney, S., Jhangiani, S.N., Zimmerman, H.H., Muzny, D.M., Wang, X., Tang, J., Medikonda, R., Ramachandran, P.V., Wong, L.J., Boerwinkle, E., Gibbs, R.A., Eng, C.M., Lalani, S.R., Hertecant, J., Rodenburg, R.J., Abdul-Rahman, O.A., Yang, Y., Xia, F., Wang, M.C., Lupski, J.R., Meisinger, C., and Sutton, V.R. (2016). MIPEP recessive variants cause a syndrome of left ventricular non-compaction, hypotonia, and infantile death. Genome Med. 8, 106.
*equal contribution

Vögtle, F.N.#, Keller, M., Taskin, A.A., Horvath, S.E., Guan, X.L., Prinz, C., Opali?ska, M., Zorzin, C., van der Laan, M., Wenk, M.R., Schubert, R., Wiedemann, N., Holzer, M., and Meisinger, C.# (2015). Mitochondrial dynamics: The fusogenic lipid phosphatidic acid promotes the biogenesis of mitochondrial outer membrane protein Ugo1. J. Cell Biol. 210, 951-960. #corresponding

Burkhart, J.M., Taskin, A.A., Zahedi, R.P., and Vögtle, F.N. (2015). Quantitative profiling for substrates of the mitochondrial presequence processing protease reveals candidates of a proteotoxic stress response. J. Proteome Res. 14, 4550-4563.

Stroud, D.A., Maher, M.J., Lindau, C., Vögtle, F.N., Frazier, A.E., Surgenor, E., Mountford, H., Singh, A.P., Bonas, M., Oeljeklaus, S., Warscheid, B., Meisinger, C., Thorburn, D.R., and Ryan, M.T. (2015). COA6 is a copper-binding complex IV assembly factor critical for biogenesis of mtDNA-encoded COX2. Hum. Mol. Genet. 24, 5404-5415.

Patterson, H.C., Gerbeth, C., Thiru, P., Vögtle, F.N., Knoll, M., Shahsafaei, A., Samocha, K.E., Huang, C.X., Harden, M.M., Song, R., Chen, C., Kao, J., Shi, J., Salmon, W., Shaul, Y.D., Stokes, M.P., Silva, J.C., Bell, G.W., MacArthur, D.G., Ruland, J., Meisinger, C., and Lodish, H. A. (2015). Respiratory Chain Controlled Signal Transduction Cascade in the Mitochondrial Intermembrane Space Mediates Hydrogen Peroxide Signaling. Proc. Natl. Acad. Sci. USA 112, E5679-5688.

Pacheu-Grau, D., Bareth, B., Dudek, J., Juris, L., Vögtle, F.N., Wissel, M., Leary, S.C., Dennerlein, S., Rehling, P., and Deckers, M. (2015). Cooperation between COA6 and SCO2 in COX2 Maturation during Cytochrome c Oxidase Assembly Links Two Mitochondrial Cardiomyopathies. Cell Metab. 21, 823-833.

Mossmann, D.*, Vögtle, F.N.*, Taskin, A.A., Teixeira, P.F., Ring, J., Burkhart, J.M., Burger, N., Pinho, C.M., Tadic, J., Loreth, D., Graff, C., Metzger, F., Sickmann, A., Kretz, O., Wiedemann, N., Zahedi, R.P., Madeo, F., Glaser, E., and Meisinger, C. (2014). Amyloid-β peptide induces mitochondrial dysfunction by inhibition of preprotein maturation. Cell Metab. 20, 662-669.        *equal contribution

Heublein, M., Burguillos, M.A., Vögtle, F.N., Teixeira, P.F., Imhof, A., Meisinger, C., and Ott, M. (2014). The novel component Kgd4 recruits the E3 subunit to the mitochondrial a-ketoglutarate dehydrogenase. Mol. Biol. Cell 25, 3342-3349.

Ieva, R., Heißwolf, A.K., Gebert, M., Vögtle, F.N., Wollweber, F., Mehnert, C.S., Oeljeklaus, S., Warscheid, B., Meisinger, C., van der Laan, M., and Pfanner, N. (2013). Mitochondrial inner membrane protease promotes assembly of presequence translocase by removing a carboxy-terminal targeting sequence. Nat. Commun. 4, 2853.

Büttner, S., Habernig, L., Broeskamp, F., Ruli, D., Vögtle, F.N., Vlachos, M., Macchi, F., Küttner, V., Carmona-Gutierrez, D., Eisenberg, T., Ring, J., Markaki, M., Taskin, A.A., Benke, S., Ruckenstuhl, C., Braun, R., Van den Haute, C., Bammens, T., van der Perren, A., Fröhlich, K.U., Winderickx, J., Kroemer, G., Baekelandt, V., Tavernarakis, N., Kovacs, G.G., Dengjel, J., Meisinger, C., Sigrist, S.J., and Madeo, F. (2013). Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease. EMBO J. 32, 3041-3054.

Venne, A.S., Vögtle, F.N., Meisinger, C., Sickmann, A., and Zahedi, R.P. (2013). Novel highly sensitive, specific, and straightforward strategy for comprehensive N-terminal proteomics reveals unknown substrates of the mitochondrial peptidase Icp55. J. Proteome Res. 12, 3823-3830.

Huai, J., Vögtle, F.N., Jöckel, L., Li, Y., Kiefer, T., Ricci, J.E., and Borner, C. (2013). TNFa-induced lysosomal membrane permeability is downstream of MOMP and triggered by caspase-mediated NDUFS1 cleavage and ROS formation. J. Cell Sci. 126, 4015-4025.

Vögtle, F.N.*, Burkhart, J.M.*, Rao, S., Gerbeth, C., Hinrichs, J., Martinou, J.C., Chacinska, A., Sickmann, A., Zahedi, R.P., and Meisinger, C. (2012). Intermembrane space proteome of yeast mitochondria. Mol. Cell. Proteomics 11, 1840-1852.
*equal contribution

Vukotic, M., Oeljeklaus, S., Wiese, S., Vögtle, F.N., Meisinger, C., Meyer, H.E., Zieseniss, A., Katschinski, D.M., Jans, D.C., Jakobs, S., Warscheid, B., Rehling, P., and Deckers, M. (2012). Rcf1 mediates cytochrome oxidase assembly and respirasome formation, revealing heterogeneity of the enzyme complex. Cell Metab. 15, 336-347.

Horvath, S.E., Böttinger, L., Vögtle, F.N., Wiedemann, N., Meisinger, C., Becker, T., and Daum, G. (2012). Processing and topology of the yeast mitochondrial phosphatidylserine decarboxylase 1. J. Biol. Chem. 287, 36744-36755.

Wilfling, F., Weber, A., Potthoff, S., Vögtle, F.N., Meisinger, C., Paschen, S.A., and Haecker, G. (2012). BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax. Cell Death Differ. 19, 1328-1336.

Vögtle, F.N., Prinz, C., Kellermann, J., Lottspeich, F., Pfanner, N., and Meisinger, C. (2011). Mitochondrial protein turnover: role of the precursor intermediate peptidase Oct1 in protein stabilization. Mol. Biol. Cell 22, 2135-2143.

Büttner, S., Ruli, D., Vögtle, F.N., Galluzzi, L., Moitzi, B., Eisenberg, T., Kepp, O., Habernig, L., Carmona-Gutierrez, D., Rockenfeller, P., Laun, P., Breitenbach, M., Khoury, C., Fröhlich, K.U., Rechberger, G., Meisinger, C., Kroemer, G., and Madeo, F. (2011). A yeast BH3-only protein mediates the mitochondrial pathway of apoptosis. EMBO J. 30, 2779-2792.

Alikhani, N., Berglund, A.K., Engmann, T., Spånning, E., Vögtle, F.N., Pavlov, P., Meisinger, C., Langer, T., and Glaser, E. (2011). Targeting capacity and conservation of PreP homologues localization in mitochondria of different species. J. Mol. Biol. 410, 400-410.

Vögtle, F.N.*, Wortelkamp, S.*, Zahedi, R.P., Becker, D., Leidhold, C., Gevaert, K., Kellermann, J., Voos, W., Sickmann, A., Pfanner, N., and Meisinger C. (2009). Global analysis of the mitochondrial N-Proteome identifies a processing peptidase critical for protein stability. Cell 139, 428-439.
*equal contribution

Jäger, S., Jahnke, A., Wilmes, T., Adebahr, S., Vögtle, F.N., Delima-Hahn, E., Pfeifer, D., Berg, T., Lübbert, M., and Trepel, M. (2007). Leukemia-targeting ligands isolated from phage-display peptide libraries. Leukemia 21, 411-420.

Sanjuán Szklarz, L.K., Kozjak-Pavlovic, V., Vögtle, F.N., Chacinska, A., Milenkovic, D., Vogel, S., Dürr, M., Westermann, B., Guiard, B., Martinou, J.C., Borner, C., Pfanner, N., and Meisinger, C. (2007). Preprotein transport machineries of yeast mitochondrial outer membrane are not required for Bax-induced release of intermembrane space proteins. J. Mol. Biol. 368, 44-54.

Review articles and book chapters

Gomez-Fabra Gala, M., and Vögtle, F.N. (2021). Mitochondrial proteases in human diseases. FEBS Lett. published online

Vögtle, F.N. (2020). Open questions on the mitochondrial unfolded protein response. Invited viewpoint, FEBS J. published online

Taskin, A.A., Poveda-Huertes, D., and Vögtle, F.N. (2019). Author's View: a nuclear transcription factor relocalizing to mitochondria rescues cells from proteotoxic aggregates. Mol. Cell. Oncol. 7, 1698256. (invited review)

Carmona-Gutierrez, D., Bauer, M.A., Zimmermann, A., Aguilera, A., Austriaco, N., Ayscough, K., Balzan, R., Bar-Nun, S., Barrientos, A., Belenky, P., Blondel, M., Braun, R.J., Breitenbach, M., Burhans, W.C., Büttner, S., Cavalieri, D., Chang, M., Cooper, K.F., Côrte-Real, M., Costa, V., Cullin, C., Dawes, I., Dengjel, J., Dickman, M.B., Eisenberg, T., Fahrenkrog, B., Fasel, N., Fröhlich, K.U., Gargouri, A., Giannattasio, S., Goffrini, P., Gourlay, C.W., Grant, C.M., Greenwood, M.T., Guaragnella, N., Heger, T., Heinisch, J., Herker, E., Herrmann, J.M., Hofer, S., Jiménez-Ruiz, A., Jungwirth, H., Kainz, K., Kontoyiannis, D.P., Ludovico, P., Manon, S., Martegani, E., Mazzoni, C., Megeney, L.A., Meisinger, C., Nielsen, J., Nyström, T., Osiewacz, H.D., Outeiro, T.F., Park, H.O., Pendl, T., Petranovic, D., Picot, S., Pol?ic, P., Powers, T., Ramsdale, M., Rinnerthaler, M., Rockenfeller, P., Ruckenstuhl, C., Schaffrath, R., Segovia, M., Severin, F.F., Sharon, A., Sigrist, S.J., Sommer-Ruck, C., Sousa, M.J., Thevelein, J.M., Thevissen, K., Titorenko, V., Toledano, M.B., Tuite, M., Vögtle, F.N., Westermann, B., Winderickx, J., Wissing, S., Wölfl, S., Zhang, Z.J., Zhao, R.Y., Zhou, B., Galluzzi, L., Kroemer, G., Madeo, F. (2018). Guidelines and recommendations on yeast cell death nomenclature. Microb. Cell 5, 4-31.

Poveda-Huertes, D., Mulica, P., and Vögtle, F.N. (2017). The versatility of the mitochondrial presequence processing machinery: cleavage, quality control and turnover. Cell Tissue Res. 367, 73-81.

Vögtle, F.N., and Meisinger, C. (2015). (Patho)physiologische Rolle von mitochondrialen Präsequenzproteasen. Biospektrum 3, 260-263.

Mossmann, D., Meisinger, C., and Vögtle, F.N. (2012). Processing of mitochondrial presequences. Biochim. Biophys. Acta 1819, 1098-1106.

Vögtle, F.N., and Meisinger, C. (2012). The mitochondrial intermediate cleaving peptidase Icp55. The Handbook of proteolytic enzymes, 3rd edition, Oxford: Academic Press, 1533-1536.  

Vögtle, F.N., and  Meisinger, C. (2012). Sensing mitochondrial homeostasis: the protein import machinery takes control. Dev. Cell 23, 234-236.

Vögtle, F.N., Schmidt, O., Chacinska, A., Pfanner, N., and Meisinger, C. (2010). Native techniques for analysis of mitochondrial protein import. Methods in Mol. Biol. 619, 425-436.