Minoia M, Quintana-Cordero J, Jetzinger K, Kotan IE, Turnbull KJ, Ciccarelli M, Masser AE, Liebers D, Gouarin E, Czech M, Hauryliuk V, Bukau B, Kramer G, Andréasson C. (2024). Chp1 is a dedicated chaperone at the ribosome that safeguards eEF1A biogenesis. Nat Commun, 15(1): 1382. URL
2023
Günnigmann M., Koubek J., Kramer G., Bukau B. (2023). Selective ribosome profiling as a tool to study interactions of translating ribosomes in mammalian cells. Methods in Enzymology. Academic Press. ISSN 0076-6879. https://doi.org/10.1016/bs.mie.2022.09.006
2022
Cerullo, F., Filbeck, S., Patil, P. R., Hung, H. C., Xu, H., Vornberger, J., Hofer, F. W., Schmitt, J., Kramer, G., Bukau, B., Hofmann, K., Pfeffer, S., & Joazeiro, C. A. P. (2022). Bacterial ribosome collision sensing by a MutS DNA repair ATPase paralogue. Nature, 603(7901), 509–514. https://doi.org/10.1038/s41586-022-04487-6
2021
Sharma, A.K., Venezian, J., Shiber, A., Kramer, G., Bukau, B., O´Brien E.P. Combinations of slow-translating codon clusters can increase mRNA half-life in Saccharomyces cerevisiae. (2021) Proc. Nat. Acad. Sci., 118: e2026362118. https://doi.org/10.1073/pnas.2026362118.
Friedrich, U.A., Zedan, M., Hessling, B., Fenzl, K., Gillet. L., Barry, J., Knop, M., Kramer, G., Bukau, B. N α-terminal acetylation of proteins by NatA and NatB serves distinct physiological roles in Saccharomyces cerevisiae. (2021) Cell Rep. 34: 108711, https://doi.org/10.1016/j.celrep.2021.108711.
Bertolini, M., Fenzl, K., Kats, I., Wruck, F., Tippmann, F. Schmitt, J., Auburger, J.J., Tans, S., Bukau, B., Kramer, G. Interactions between nascent proteins translated by adjacent ribosomes drive homomer assembly. (2021) Science 371: 57-64, doi: https://doi.org/10.1126/science.abc7151.
2020
Ahmed, N., Friedrich, U.A., Sormanni, P., Ciryam, P., Altman, N.S., Bukau, B., Kramer, G., O'Brien, E.P. Pairs of amino acids at the P- and A-sites of the ribosome predictably and causally modulate translation-elongation rates. (2020) J. Mol. Biol. S0022-2836(20)30614-8. doi: 10.1016/j.jmb.2020.10.030. Online ahead of print. (Abstract).
Bohlen, J., Harbrecht, L., Blanco, S., Clemm von Hohenberg, K., Fenzl, K., Kramer, G., Bukau, B., Teleman, A.A. DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4. (2020) Nat. Commun. 11:4676. doi: 10.1038/s41467-020-18452-2. (Abstract).
Bohlen, J., Fenzl, K., Kramer, G., Bukau, B., Teleman, A.A. Selective 40S footprinting reveals cap-tethered ribosome scanning in human cells. (2020) Mol. Cell S1097-2765(20)30390-7. doi: 10.1016/j.molcel.2020.06.005. (Abstract).
2019
Castells-Ballester, J., Rinis, N., Kotan, I., Gal, L., Bausewein, D., Kats, I., Zatorska, E., Kramer, G., Bukau, B., Schuldiner, M., Strahl, S. Translational Regulation of Pmt1 and Pmt2 by Bfr1 Affects Unfolded Protein O-Mannosylation. (2019) Int. J. Mol.Sci. 20(24). pii: E6220. doi: 10.3390/ijms20246220. (Abstract).
Rusu, P., Shao, C., Neuerburg, A., Acikgöz, A.A., Wu, Y., Zou, P., Phapale, P., Shankar, T.S., Döring, K., Dettling, S., Körkel-Qu, H., Bekki, G., Costa, B., Guo, T., Friesen, O., Schlotter, M., Heikenwalder, M., Tschaharganeh. D.F., Bukau, B., Kramer, G., Angel, P., Herold-Mende, C., Radlwimmer, B., Liu, H.K. GPD1 Specifically Marks Dormant Glioma Stem Cells with a Distinct Metabolic Profile. (2019) Cell Stem Cells pii: S1934-5909(19)30268-1. doi: 10.1016/j.stem.2019.06.004. (Abstract).
Jamshad, M., Knowles, T.J., White, S.A., Ward, D.G., Mohammed, F., Rahman, K.F., Wynne, M., Hughes, G.W., Kramer, G., Bukau, B., Huber, D. The C-terminal tail of the bacterial translocation ATPase SecA modulates its activity. (2019) Elife pii: e48385. doi: 10.7554/eLife.48385 (Abstract).
2018
Kramer, G., Shiber, A., Bukau, B. Mechanisms of Co-Translational Maturation of Newly Synthesized Proteins. (2018) Ann. Rev. Biochem., doi: 10.1146/annurev-biochem-013118-111717 (Abstract).
Shiber, A., Döring, K., Friedrich, U., Klann, K., Merker, D., Zedan, M., Tippmann, F., Kramer, G., Bukau, B. (2018) Co-translational assembly of protein complexes in eukaryotes revealed by ribosome profiling. Nature, doi: 10.1038/s41586-018-0462-y (Abstract).
2017
Acosta-Sampson, L., Döring, K., Lin, Y., Yu, V.Y., Bukau, B., Kramer, G., Cate, J.H.D. Role for Ribosome-Associated Complex and Stress-Seventy subfamily B (RAC-Ssb) in integral membrane protein translation. (2017) J. Biol. Chem. pii: jbc.M117.813857. doi: 10.1074/jbc.M117.813857. (Abstract).
Döring, K., Ahmed, N., Riemer, T., Suresh, H.G., Vainshtein, Y., Habich, M., Riemer, J., Mayer, M.P., O'Brien, E.P., Kramer, G., Bukau, B. Profiling Ssb-nascent chain interactions reveals principles of Hsp70-assisted folding. (2017) Cell 170:298-311.e20. doi: 10.1016/j.cell.2017.06.038. (Abstract).
2016
Mashaghi, A., Bezrukavnikov, S., Minde, D.P., Wentink, A.S., Kityk, R., Zachmann-Brand, B., Mayer, M.P., Kramer, G., Bukau, B., Tans, S.J. Alternative modes of client binding enable functional plasticity of Hsp70. (2016) Nature 539, 448-451 (Abstract).
Huber, D., Jamshad, M., Hanmer, R., Schibich, D., Döring, K., Marcomini, I., Kramer, G., Bukau, B. SecA cotranslationally interacts with nascent substrate proteins in vivo. (2016) J. Bacteriol. pii: JB.00622-16. Epub ahead of print. (Abstract).
Lange, S., Franks, W.T., Rajagopalan, N., Döring, K., Geiger, M.A., Linden, A., van Rossum, B.J., Kramer, G., Bukau, B., Oschkinat, H. Structural analysis of a signal peptide inside the ribosome tunnel by DNP MAS NMR. (2016) Sci. Adv. 2, e1600379. doi: 10.1126/sciadv.1600379. eCollection 2016 Aug. (Abstract).
Schibich, D., Gloge, F., Pöhner, I., Björkholm, P., Wade, R.C., von Heijne, G., Bukau, B., Kramer, G. Global profiling of SRP interaction with nascent polypeptides. (2016) Nature 536, 219-223, doi: 10.1038/nature19070 (Abstract).
Nilsson, O.B., Müller-Lucks, A., Kramer, G., Bukau, B., von Heijne, G. Trigger factor reduces the force exerted on the nascent chain by a cotranslationally folding protein. (2016) J. Mol. Biol. 428, 1356-1364, pii: S0022-2836(16)00130-3. doi: 10.1016/j.jmb.2016.02.014. (Abstract)
Nissley, D.A., Sharma, A.K., Ahmed, N., Friedrich, U.A., Kramer, G., Bukau, B., O'Brien, E.P. Accurate prediction of cellular co-translational folding indicates proteins can switch from post- to co-translational folding. (2016) Nat. Commun. 7, 10341. doi: 10.1038/ncomms10341. (Abstract)
2015
Cherkasov, V., Grousl, T., Theer, P., Vainshtein, Y., Gläßer, C., Mongis, C., Kramer, G., Stoecklin, G., Knop, M., Mogk, A., Bukau, B. Systemic control of protein synthesis through sequestration of translation and ribosome biogenesis factors during severe heat stress. (2015) FEBS Lett. 589, 3654-3664. doi: 10.1016/j.febslet.2015.10.010. (Abstract).
Shieh, Y.-W., Minguez, P., Bork, P., Auburger, J.J., Guilbride, D.L., Kramer, G., Bukau, B. Operon structure and cotranslational subunit association direct protein assembly in bacteria. (2015) Science 350, 678 - 680 (Abstract).
Kramer, G., Bukau, B. 18 The busy life of nascent chains: mechanisms of folding of newly synthesized proteins. (2015) J. Biomol. Struct. Dyn. 33 Suppl 1:10. doi: 10.1080/07391102.2015.1032558 (Abstract).
Kramer, G., Guilbride, D.L., Bukau, B. Cell Biology. Finding nascent proteins the right home. (2015) Science 348, 182-183 (Summary | Full text | Reprint).
2014
Hsieh T.Y., Nillegoda, N.B., Tyedmers, J., Bukau, B., Mogk, A., Kramer, G. Monitoring protein misfolding by site-specific labeling of proteins in vivo. (2014) Plos One 9(6):e99395 (Abstract).
Gloge, F., Becker, A.H., Kramer, G., Bukau, B. Co-translational mechanisms of protein maturation. (2014) Curr. Opin. Struct. Biol. 24, 24-33 (Abstract).
2013
Becker, A.H., Oh, E., Weissman, J. S., Kramer, G., Bukau, B. Selective ribosome profiling as a tool to study the interaction of chaperones and targeting factors with nascent polypeptide chains and ribosomes. (2013) Nature Protocols 8, 2212-2239 (Abstract).
Mashaghi, A., Kramer, G., Bechtluft, P., Zachmann-Brand, B., Driessen, A. J., Bukau, B., Tans, S. J. Reshaping of the conformational search of a protein by the chaperone trigger factor. (2013) Nature 500, 98-101 (Abstract).
Sandikci, A., Gloge, F., Martinez, M., Mayer, M.P., Wade, R., Bukau, B., Kramer, G. Dynamic enzyme docking to the ribosome coordinates N-terminal processing with polypeptide folding. (2013) Nat. Struct. Mol. Biol. 20, 843-850 (Abstract).
2012
Hoffmann, A., Becker, A.H., Zachmann-Brand, B., Deuerling, E., Bukau, B., Kramer, G. Concerted action of the ribosome and the associated chaperone trigger factor confines nascent polypeptide folding. (2012) Mol. Cell 48, 63-74 (Abstract).
2011
Oh, E., Becker, A.H., Sandikci, A., Huber, D., Chaba, R., Gloge, F., Nichols, R.J., Typas, A., Gross, C.A., Kramer, G., Weissman, J.S., Bukau, B. Selective ribosome profiling reveals the cotranslational chaperone action of trigger factor in vivo. (2011) Cell 147, 1295-1308 (Abstract).
Huber, D., Rajagopalan, N., Preissler, S., Rocco, M.A., Merz, F., Kramer, G., Bukau, B. SecA interacts with ribosomes in order to facilitate posttranslational translocation in bacteria. (2011) Mol. Cell 41, 343-353 (Abstract).
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