ZMBH Research Group Leader
Im Neuenheimer Feld 282
69120 Heidelberg, Germany
Tel. +49 (0) 6221 - 545854
Fax +49 (0) 6221 - 545893
Welcome to the Kaessmann lab
(for further information, also see our previous website in Lausanne: http://www.unil.ch/cig/kaessmann)
Mammals are characterized by specific phenotypic traits that include lactation, hair, and relatively large brains with unique structures. Individual mammalian lineages have, in turn, evolved characteristic traits that distinguish them from others. These include obvious anatomical differences but also differences related to reproduction, life span, cognitive abilities, behavior, and disease susceptibility. The molecular changes (i.e., changes in protein/RNA sequences or expression levels) underlying these phenotypic shifts and the associated selective pressures have only recently begun to be investigated based on an increasing number of available mammalian genomes. Our group performs integrated bioinformatics analyses pertaining to the functional evolution of mammalian genes (and associated phenotypic changes) on the basis of publicly available genomic data as well as data generated by the wet lab unit of the group. We have been interested in a range of topics related to the functional evolution of genomes from primates and other mammals. In the framework of our current projects, we are producing large amounts of transcriptome and genome (e.g., epigenome) data for a unique collection of tissues from representative mammals and outgroup species (e.g., birds) using next generation sequencing technologies. Topics of current projects that are based on these data include the origins and/or functional evolution of protein-coding genes, alternative splicing, long noncoding RNAs, microRNAs, and sex chromosomes.
Warnefors, M., Mössinger, K., Halbert, J., Studer, T., VandeBerg, J.L., Lindgren, I., Fallahshahroudi, A., Jensen, P., Kaessmann, H. (2017) Sex-biased microRNA expression in mammals and birds reveals underlying regulatory mechanisms and a role in dosage compensation. Genome Res. (in press).
Henrichsen, C., Vinckenbosch, N., Zöllner, S., Chaignat, E., Pradervand, S., Frédéric Schütz, Ruedi, M., *Kaessmann, H. and *Reymond, A. (2009) Segmental copy number variation shapes tissue transcriptomes. Nat. Genet. 41: 424-429. URL
Rosso, L., Marques, A. C., Weier, M., Lambert, N., Lambot, M. A., Vanderhaeghen, P., and Kaessmann, H. (2008) Birth and rapid subcellular adaptation of a hominoid-specific CDC14 protein. PLoS Biol. 6:e140. URL
Potrzebowski, L., Vinckenbosch, N., Marques, A. C., Chalmel, F., Jegou, B., and Kaessmann, H. (2008) Chromosomal Gene Movements Reflect the Recent Origin and Biology of Therian Sex Chromosomes. PLoS Biol. 6:e80. URL
Necsulea, A. and Kaessmann, H. (2014) Evolutionary dynamics of coding and noncoding transcriptomes. Nat. Rev. Genet. 5: 734-48. URL
Kaessmann, H. (2010) Origins, evolution and phenotypic impact of new genes. Genome Res. 20: 1313-1326. URL
Kaessmann, H., Vinckenbosch, N., and Long, M. (2009) RNA-based gene duplication: mechanistic and evolutionary insights. Nat. Rev. Genet. 10: 19-31. URL
* = equal contribution