Open Positions in the Schiebel Lab
Are you passionate about cell biology and eager to explore the fascinating world of centrioles? We invite applications for a PhD position focusing on centriole biogenesis.
PhD position "Centriole Duplication"
About the position:
The successful candidate will join our research group, renowned for its work on gamma-tubulin complexes, centrioles and centrosome function. This PhD project will investigate the molecular mechanisms underlying centriole biogenesis, with a focus on understanding how centrioles duplicate and assemble microtubules during formation. The research will combine advanced microscopy techniques, biochemistry, and genetic tools to unravel the complexities of centriole assembly and function and how this can lead to disease.
Qualifications:
• A Master’s degree or equivalent in Cell Biology, Molecular Biology, Biochemistry, or a related field
• Passionate about science
How to Apply:
Interested candidates should send their application, including a CV, cover letter, and contact information for two references, to Prof. Elmar Schiebel at schiebel.elmar@zmbh.uni-heidelberg.de. The PhD student will be a member of the Heidelberg Biosciences International Graduate School (HBIGS) (http://www.hbigs.uni-heidelberg.de/). This PhD position is initially funded for 3 years.
Relevant recent publications:
1 Liu, P. et al. Insights into the assembly and activation of the microtubule nucleator gammaTuRC. Nature 578, 467-471 (2020). https://doi.org:10.1038/s41586-019-1896-6
2 Würtz, M. et al. Modular assembly of the principal microtubule nucleator ?-TuRC. Nat Comm 473, doi: 10.1038/s41467-41022-28079-41460 (2022).3 Karasu, O. R., Neuner, A., Atorino, E. S., Pereira, G. & Schiebel, E. The central scaffold protein CEP350 coordinates centriole length, stability, and maturation. J Cell Biol 221 (2022). https://doi.org:10.1083/jcb.202203081
4 Gao, Q. et al. The structure of the gamma-TuRC at the microtubule minus end - not just one solution. Bioessays, e2400117 (2024). https://doi.org:10.1002/bies.2024001175 Vermeulen, B. J. et al. gamma-TuRC asymmetry induces local protofilament mismatch at the RanGTP-stimulated microtubule minus end. EMBO J (2024). https://doi.org:10.1038/s44318-024-00087-4
Are you passionate about cell biology and eager to explore the fascinating world of centrioles? We invite applications for a Master position focusing on centriole duplication. About the Position: The successful candidate will join Prof. Elmar Schiebel’s research group, renowned for its work on gamma-tubulin, centrioles and centrosome function. This Master project will investigate the molecular mechanisms underlying centriole duplication. The research will combine advanced microscopy techniques, biochemistry, and genetic tools to unravel the complexities of centriole assembly and function. The Master student will be supported by a Hiwi contract of ca. 500 € per month.
Master thesis "Centriole Duplication"
How to Apply:
Interested candidates should send their application, including a CV, cover letter, and contact information for two references, to Prof. Elmar Schiebel at schiebel.elmar@zmbh.uni-heidelberg.de.
Relevant recent publications:
1 Liu, P. et al. Insights into the assembly and activation of the microtubule nucleator gammaTuRC. Nature 578, 467-471 (2020). https://doi.org:10.1038/s41586-019-1896-6
2 Würtz, M. et al. Modular assembly of the principal microtubule nucleator ?-TuRC. Nat Comm 473, doi: 10.1038/s41467-41022-28079-41460 (2022).3 Karasu, O. R., Neuner, A., Atorino, E. S., Pereira, G. & Schiebel, E. The central scaffold protein CEP350 coordinates centriole length, stability, and maturation. J Cell Biol 221 (2022). https://doi.org:10.1083/jcb.202203081
4 Gao, Q. et al. The structure of the gamma-TuRC at the microtubule minus end - not just one solution. Bioessays, e2400117 (2024). https://doi.org:10.1002/bies.2024001175 Vermeulen, B. J. et al. gamma-TuRC asymmetry induces local protofilament mismatch at the RanGTP-stimulated microtubule minus end. EMBO J (2024). https://doi.org:10.1038/s44318-024-00087-4