Ruprecht-Karls-Universität Heidelberg

Contact us:
Zentrum fr Molekulare Biologie der Universitt Heidelberg (ZMBH)
Im Neuenheimer Feld 282
Room 401
69120 Heidelberg, Germany
Tel.: +49-6221-54 6813
Fax: +49-6221-54 5894
ms-service@zmbh.uni-heidelberg.de

Logo ZMBH Welcome to the Core Facility for Mass Spectrometry & Proteomics (CFMP) at the ZMBH


Our mission is to provide researchers of the Heidelberg Life Science Campus state-of-the-art high-performance mass spectrometry services. These services include all aspects of protein characterization and qualitative and quantitative proteomics:

- Protein identification from 1D and 2D-gels
- Quantification based on label-free (spectral counting, peptide intensities, MaxQuant-LFQ) and isotope labeling (SILAC & reductive dimethyl labeling) techniques 
- Detection and localization of posttranslational modifications (PTMs)
- Deciphering the interactome of target proteins








Established procedures allow the exploratory analysis of the protein content of cells and organisms and their temporal qualitative and quantitative changes that accompany development, reaction to environmental impacts and pathophysiological processes. Targeted proteomics strategies of high accuracy and sensitivity, such as multiple reaction monitoring (MRM), have been set up for quantitative analysis of known protein networks. Furthermore, the conformation of proteins can be analyzed using amide hydrogen exchange (HDX) mass spectrometry, which allows the analysis of protein mechanics, protein-protein interaction interfaces and ligand-induced allosteric conformational changes.



NEWS

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Dear customers,

please find below dates for new workshops offered by the core facility. The workshops provide hands-on training for the interpretation of data from our MS facility.

04.12.17
Protein Identification by Mass Spectrometry

05.12.17 PTMs of Proteins by Mass Spectrometry

06.12.17 Proteomics: Quantification of Proteins in Complex Mixtures

07.12.17 Targeted Proteomics for Sensitive and Robust Quantification

For registration details, see the flyer below:



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Financial Support

ZMBH, DKFZ-ZMBH-Alliance, CellNetworks, HMLS, DKFZ, SFB1036, SFB 638, Graduiertenkolleg 1188, Transregio 83.