University of Heidelberg

ZMBH - Open Positions


Scientific Job Openings

 
Listed 4.8.17  
 

IMAGE ANALYSIS SPECIALIST at the ZMBH Light Microscopy Core Facility

The ZMBH Imaging Facility seeks to recruit a highly motivated individual to join its team working in the light microscopy core facility in an academic research environment. The Imaging Facility employs a broad range of imaging technologies, is equipped with state-of-the-art microscopes and has a number of research groups working at the interface of biology and biophysics as well as imaging technology development (e.g. superresolution microscopy). This provides an exciting and unique opportunity to work on image processing and analysis in a multidisciplinary environment with researchers in the life sciences.
Remuneration will be based on qualification and the salary structure of the TV-L (public service tariff scale). The initial contract is limited to 2 years.

Responsibilities Include

• Manage image processing software (ImageJ/Fiji,..).
• Help scientists design and build successful image analysis pipelines and data flows using a variety of open source and commercial software packages (ImageJ macro language, Java, Python, MATLAB).
• Manage a “walk-in” advisory service for scientists to guide them to the correct software and image analysis solution.
• Train staff and graduate students in image analysis techniques through workshops and practical courses.
• Collaborate with researchers by writing/implementing algorithms to solve image processing problems from cell biology microscopy data.
• Manage, test and evaluate image acquisition software of microscope systems.
• Maintain the computer workstations of the ZMBH Imaging Facility.

Essential Requirements

• Proven experience applying and/or developing image analysis tools and applications with ImageJ/Fiji, MATLAB, Java or equivalent programming language.
• A university degree (Master degree or, ideally, a PhD) in Biology, Physics, Computer Science, Mathematics or equivalent qualification (e.g. Electrical Engineering).
• Ability to work in a team.
• Experience in light microscopy is welcome but not required.
• Ability to give courses in image processing and analysis.
• Must be fluent in English and have excellent communication skills both verbal and written. Fairly basic German language skills are needed.

Contact

Please send your CV and relevant documents by email to Dr. Holger Lorenz (h.lorenz@zmbh.uni-heidelberg.de) with the subject “Image Analysis Specialist”. The application deadline is 31.8.2017 but applications will be processed as they are received.

 
Listed 3.7.17  

Predoctoral Position MCM Group HITS-04-2017

Opening for a Ph.D. student in the Molecular and Cellular Modelling group at the Heidelberg Institute for Theoretical Studies (HITS gGmbH) in Heidelberg, Germany

We are seeking a highly motivated scientist to join the Molecular and Cellular Modelling group at HITS as a Ph.D. student as soon as possible. The research project will focus on the development of Brownian dynamics simulation methods implemented in our SDA software (http://mcm.h-its.org/sda) and their application to investigate biomolecular diffusion, binding kinetics, and the effects of macromolecular crowding.
HITS is a private non-profit research institute carrying out multidisciplinary research in the computational sciences. It receives its base funding from the HITS Foundation.
The Molecular and Cellular Modeling group is an interdisciplinary research group that works on the development and application of computer-aided methods to model and simulate biomolecular interactions. The focus is on proteins and the computational approaches are mostly based on the three-dimensional structures of macromolecules. Techniques cover a wide spectrum from interactive, web-based visualization tools to molecular and Brownian dynamics simulations (see http://www.h-its.org/mcm ).
Candidates should possess a Master’s Degree or equivalent qualification in biophysics, biochemistry, physics, scientific computing, or a related discipline. Candidates should preferably have a strong theoretical background, experience in biomolecular modelling and simulation, possess excellent programming skills, and have a genuine interest in interdisciplinary research.
To apply, please enter your application materials at the following link: https://application.h-its.org/intern/register.php?id=0vtstn0

The application deadline is 7.7.2017 but applications will be processed as they are received.
Please note that applications not submitted via the online system will not be considered.
Informal enquiries may be addressed to Prof. Rebecca Wade (rebecca.wade(at)h-its.org)

 
Listed 29.6.17  

PhD position: “Role of Human Ubiquitin-like ISG15 in Cancer Development”
Centre for Molecular Biology (ZMBH)
Heidelberg University

The Interferon-Stimulated Gene 15 product, ISG15, modifies proteins in a similar manner to ubiquitin. ISG15 appears to play important roles in various biological and cellular functions including innate immunity, cell adaptation to actin defects and DNA damage. In addition, overexpression of ISG15 has been shown to contribute to metastatic abilities of certain breast cancer cell lines suggesting that ISG15 promotes tumor formation. However, relative to ubiquitin, substrates of ISG15 and the molecular consequences of this conjugation are still poorly understood. Recently, we have identified the human Ras GTPase-activating-like protein IQGAP1, a scaffold protein that interacts with RAC1 and CDC42, as an ISG15 substrate. ISGylation of IQGAP1 has an impact on the interaction of RAC1 and CDC42 with IQGAP1 and the activity of these GTPases.
In this project we will identify substrates of ISG15 by affinity purification and mass spectrometry-based approaches and study the consequences of substrate ISGylation for normal cell growth and in malignancy. ISG15 substrates will be analysed using CRISPR/Cas9 knockin and knockout strategies. We will test the impact of ISGylation on cell migration using the wound healing assay and random cell migration.
Highly motivated PhD students with a background in cell biology or molecular biology should apply. Successful candidates will be part of an international team of PhD students and postdocs that works at the forefront of scientific research (http://www.cell.com/developmental-cell/meet-the-author/berati-cerikan). The PhD student will be a member of the Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (http://www.hbigs.uni-heidelberg.de/). The PhD position is funded for 3 years.
Please send applications to E. Schiebel (schiebel.elmar@zmbh.uni-heidelberg.de).

Relevant publications from our laboratory:

Cerikan, B., R. Shaheen, G.P. Colo, C. Gläßer, S. Hata, K.-P. Knobeloch, F.S. Alkuraya, R. Fässler, and E. Schiebel. (2016). Cell intrinsic adaptation arising from chronic ablation of a key Rho GTPase regulator. Dev. Cell, 39:28-43.

Cerikan B. and E. Schiebel. (2017). Mechanism of cell-intrinsic adaptation to Adams-Oliver Syndrome gene DOCK6 disruption highlights ubiquitin-like modifier ISG15 as a regulator of RHO GTPases. Small GTPases, 23:1-8.

Chen, N.-P., B. Uddin, R. Hardt, W. Ding, M. Panic, I. Lucibello, P. Kammerer, T. Ruppert and E. Schiebel. (2017). Human phosphatase CDC14A regulates actin organization through dephosphorylation of epithelial protein lost in neoplasm. Proc. Natl. Acad. Sci. U S A, 114:5201-5206.

Chen, N.-P., B. Uddin, R. Voit, and E. Schiebel. (2016). Human phosphatase CDC14A is recruited to the cell leading edge to regulate cell migration and adhesion. Proc. Natl. Acad. Sci. USA, 113:990-995.

 
Listed 29.6.17  

PhD position: “Microtubule biology
Centre for Molecular Biology (ZMBH)
Heidelberg University

Microtubules are highly dynamic polymers that assemble at centrosomes, chromatin and pre-exiting microtubules. They are essential for cell organization including Golgi positioning, intracellular transport, cell migration and chromosome segregation in mitosis and meiosis. Shortly after assembly, microtubules become severed and capped at their minus end by stabilizing factors such as CAMSAP/Patronin. Here we will analyse how microtubules are spatially assembled in cells, how they become released from nucleation sites and captured by the Golgi and appendages of centrosomes.

The PhD student will use biochemical approaches, super resolution microscopy (STED), electron microscopy (negative stain and cryo-EM), CRISPR/Cas9 technology and live cell imaging to study microtubules and associated proteins.
Highly motivated PhD students with a background in biochemistry, cell biology or molecular biology should apply. Successful candidates will be part of an international team of PhD students and postdocs that works at the forefront of scientific research. The PhD student will be a member of the Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (http://www.hbigs.uni-heidelberg.de/). The PhD position is funded for 3 years.

Please send applications to E. Schiebel (schiebel.elmar@zmbh.uni-heidelberg.de).

Relevant publications:

1          Lin, T. C et al. MOZART1 and gamma-tubulin complex receptors are both required to turn gamma-TuSC into an active microtubule nucleation template. J. Cell Biol 215, 823-840. pii:jcb.201606092 (2017).
2          Chinen, T. et al. The gamma-tubulin-specific inhibitor gatastatin reveals temporal requirements of microtubule nucleation during the cell cycle. Nat Commun 6, 8722, doi:10.1038/ncomms9722 (2015).           
3          Lin, T. C. et al. Cell-cycle dependent phosphorylation of yeast pericentrin regulates gamma-TuSC-mediated microtubule nucleation. Elife 3, e02208, doi:10.7554/eLife.02208 (2014).
4          Gombos, L. et al. GTP regulates the microtubule nucleation activity of gamma-tubulin. Nat Cell Biol 15, 1317-1327, doi:ncb2863 [pii]10.1038/ncb2863 (2013).
5          Erlemann, S. et al. An extended γ-tubulin ring functions as a stable platform in microtubule nucleation. J Cell Biol 197, 59-74, doi:jcb.201111123 [pii]10.1083/jcb.201111123 (2012).

Reviews:

Lin, T. C., Neuner, A. & Schiebel, E. Targeting of gamma-tubulin complexes to microtubule organizing centers: conservation and divergence. Trends Cell Biol 25, 296-307, doi:10.1016/j.tcb.2014.12.002 (2015).

 
Listed 29.3.16  

1) Postdoctoral positions are available in the Joazeiro laboratory.

Research in the laboratory investigates the function of E3 ubiquitin ligases in biology and disease (Deshaies & Joazeiro, 2009. Annu Rev Biochem. 78:399-434). The positions available are to elucidate the mechanism of action of the Listerin/Ltn1 E3 ligase in ribosome-associated protein quality control, and/or to understand how defects in Listerin function cause neurodegeneration.

We had previously reported on a new mouse model of ALS/motor neuron disease caused by mutation of Listerin, whose function was unknown at the time (Chu et al. 2009. PNAS 106:2097-103). Listerin is conserved in eukaryotes, so we utilized S. cerevisiae to study its function and found that this E3 is associated with the large ribosomal subunit and mediates quality control of aberrant nascent polypeptides (Bengtson & Joazeiro 2010. Nature 467:470-3; Lyumkis et al 2014. PNAS 111:15981-6).

Our research team undertakes different approaches to study the Listerin pathway, including biochemistry, yeast genetics, structural biology, mammalian tissue culture, and gene-disease association studies using ALS patient samples. We are also well positioned to uncover novel molecular mechanisms underlying neurodegeneration by applying the discoveries we make with these approaches to studies involving the Listerin-mutant mouse model.

The candidate is expected to be proactive and productive, and should have strong background in biochemistry and molecular biology.

Please send CV, a paragraph on current and future research interests, and the names and contact information of three references to Claudio Joazeiro (c.joazeiro@zmbh.uni-heidelberg.de).

 
Listed 20.3.17  
 

The ZENTRUM FÜR MOLEKULARE BIOLOGIE (ZMBH) at Heidelberg University (Germany) is an internationally recognized research center for fundamental research in molecular and cell biology located in one of the largest German campuses for the life sciences. We invite applications from scientists for a

JUNIOR GROUP LEADER POSITION
IN SINGLE PARTICLE ANALYSIS OF MACROMOLECULAR PROTEIN ASSEMBLIES by CRYO ELECTRON MICROSCOPY

The successful candidate will establish an independent research group at the ZMBH for five years with the possibility of extension for up to six additional years. It is expected that his/her research program will extend and complement the spectrum of research topics of the ZMBH and the local community, such as cellular quality control and damage response mechanisms (http://www.zmbh.uni-heidelberg.de/sfb1036/) or spatiotemporal regulation of mitosis. The group will have access to a Krios EM with DED and additional TEM equipment.

The holder of the position will receive a start-up package and institutional support. He/she is expected to also attract external funding and to participate in the department's teaching program in the Faculty of Biosciences (in German or English).

The ZMBH houses 15 independent research groups. We offer an excellent and international research environment, which is further complemented by numerous university institutes and research centers. There are several in-house scientific core facilities, i.e. protein analytics including mass spectrometry, advanced light microscopy, flow cytometry, moreover mechanical and electrical workshops and centralized administrative services are available. Additional nearby facilities on campus include the EM Core Facility. Our Alliance with the German Cancer Research Center (DKFZ-ZMBH Alliance) provides scientific interactions and access to central facilities and scientific infrastructure of the DKFZ.

More information on the research and teaching programs as well as on the scientific facilities can be found on our website (http://www.zmbh.uni-heidelberg.de).
The University of Heidelberg has a policy of raising the proportion of women in academic positions and therefore specifically invites the application of qualified female scientists.
Under German law disabled applicants with full qualifications are to be preferred.

Further details can be obtained from Prof. Dr. Bernd Bukau, telephone +49-6221-546850, telefax: +49-6221-545507. Applications should be sent to the Director of the ZMBH, Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany (e-mail: direktor@zmbh.uni-heidelberg.de) by April 30, 2017.

Also published on naturejobs: http://www.nature.com/naturejobs/science/jobs/609327-junior-group-leader-position-in-single-particle-analysis-of-macromolecular-protein-assemblies-by-cryo-electron-microscopy

   
Listed 17.5.17  
 

The Centre for Molecular Biology of the University of Heidelberg (ZMBH) is seeking

 

a bioinformatician (PhD student or post-doc)

 

to develop novel data analysis methods for experiments in functional genomics, focusing initially on ribosomal footprinting assays performed to elucidate the interplay of ribosomes and chaperones. The position will be shared between two ZMBH groups: the group of Dr. Günter Kramer / Prof. Bernd Bukau and the group of Dr. Simon Anders.

The ideal post-doctoral candidate has experience in preprocessing, analysing, visualizing and interpreting high-throughput sequencing data, knowledge of functional genomics and of applied statistics and is able to independently develop tailored analysis code using suitable programming languages such as R or Python.

We also welcome applications from candidates for a PhD position; here we expect good skills in bioinformatics, general knowledge of molecular biology, and some prior experience using R, Python or similar languages.
Fluency in written and spoken English and interdisciplinary communication skills are critical.

We offer a securely funded position in the stimulating research environment of Heidelberg campus –a major hub for life sciences in Europe–, working with data from state-of-the-art instruments and innovative experimental approaches, interaction with and supervision by experienced biologists and bioinformaticians/biostatisticians, and so the chance to publish on cutting-edge research work.

For details, please see the Bukau and Anders groups' web pages at www.zmbh.uni-heidelberg.de or contact S. Anders or G. Kramer (s.anders@ and g.kramer@zmbh.uni-heidelberg.de). To apply, please send an e-mail with your CV and a cover letter describing your expertise and research interests to S. Anders.

   
Listed 17.5.17  
 

The German Cancer Research Centre (DKFZ), Research Group of Prof. Ana Martin-Villalba, in collaboration with the Centre for Molecular Biology of the University of Heidelberg (ZMBH), Project Group of Dr. Simon Anders, are jointly seeking

a PhD student in bioinformatics / computational science.

The Martin-Villalba group employs single-cell transcriptomics techniques to study neuronal stem cells, the Anders groups works on bioinformatics methods for exploration of and inference on omics data. The PhD project will be on the development of new analysis methods for single-cell RNA-Seq data and their application on the biological questions researched in the Martin-Villalba lab, especially regarding the role of glial stem cells in neuroregeneration.
We welcome applications not only from bioinformatricians but also from scientists of other quantitative sciences (such as mathematicas, physics, statistics, engineering, computer science) with a strong interest in molecular biology. The ideal candidate has passion strong skills in at least one of the areas scientific software development, quantitative data analysis or computational methods. Previous expertise in working with molecular-biology or other high-dimensional data would be of advantage. Furthermore, we expect passion for science, independent thinking, fluency in written and spoken English and interdisciplinary communication skills.

We offer rewarding work on applied projects, in the stimulating research environment of Heidelberg, and in tight collaboration with both experimental as well as computational scientists, providing you the chance to gain experience in diverse research topics and so get an optimal start for your scientific career.

For details on the two groups' projects and research topics, please see our web pages (here and here) or contact Prof. Martin-Villalba or Dr. Anders.

To apply, please send your CV and a cover letter describing your expertise and research interests to S. Anders (s.anders@zmbh.uni-heidelberg.de). If possible please also include a “work sample” (e.g., a technical report on a homework project, or a link to a github repo) suitable to demonstrate your coding or data analysis skills.

   
Listed 17.5.17  

The new project group of Dr. Simon Anders at the Centre for Molecular Biology of the University of Heidelberg (ZMBH) is researching bioinformatics methodology for big data in molecular biology. We develop novel statistical inference methods for various types of high-throughput sequencing assays, and novel tools for visual and interactive exploratory analysis of multi-omics data.

To build up our cross-disciplinary team, we are seeking

 

one PhD student or post-doctoral scientist

 

with expertise in computational science.

We are interested not only in bioinformaticians but also in scientists from other quantitative fields, such as computer science, engineering, mathematics, or physics.

The ideal candidate has passion for science, interest in molecular biology, and strong skills in scientific software development or quantitative data analysis or computational methods. Previous expertise in working with molecular-biology or other high-dimensional data would be of advantage. Fluency in written and spoken English and interdisciplinary communication skills are a must. For candidates for the post-doctoral position, we also expect a track record of successful work in a computational project that required innovation on the methods part.

We offer rewarding work on applied projects, in a stimulating research environment and in tight collaboration with experimental basic biology as well as clinical research groups, with access to all the resources and expertises necessary for success.

For details on our group's projects, please see our web page or contact Dr. Anders.

To apply, please send your CV and a cover letter describing your expertise and research interests to S. Anders (s.anders@zmbh.uni-heidelberg.de). If possible please also include a “work sample” (e.g., a technical report on a project, or a link to a github repo) suitable to demonstrate your coding or data analysis skills.

 
Listed 17.5.17  

Anders Group: Open positions

We are always interested in

 

talented students for internships

 

with skills in software developments.

If you want to hone your programming skills on interesting projects related to scientific software development and omics data exploration, and want to get experience in collaborative research in molecular biology, get in contact.

 

 



Non-Scientific Job Openings

   
   

 

 

to top of page

Additional positions for research assistants and non-scientific personnel are also regularly published on the pages of the University's central job market:

Central job market of the University



to top of page