Ruprecht-Karls-Universität Heidelberg

Contact us:
Zentrum fr Molekulare Biologie der Universitt Heidelberg (ZMBH)
Im Neuenheimer Feld 282
Room 401
69120 Heidelberg, Germany
Fax: +49-6221-54 5894
ms-service@zmbh.uni-heidelberg.de

Logo ZMBH Welcome to the Core Facility for Mass Spectrometry & Proteomics (CFMP) at the ZMBH


Our mission is to provide researchers of the Heidelberg Life Science Campus state-of-the-art high-performance mass spectrometry services. These services include all aspects of protein characterization and qualitative and quantitative proteomics:

- Protein identification from 1D and 2D-gels
- Quantification based on label-free (spectral counting, peptide intensities, MaxQuant-LFQ) and isotope labeling (SILAC & reductive dimethyl labeling) techniques 
- Detection and localization of posttranslational modifications (PTMs)
- Deciphering the interactome of target proteins








Established procedures allow the exploratory analysis of the protein content of cells and organisms and their temporal qualitative and quantitative changes that accompany development, reaction to environmental impacts and pathophysiological processes. Targeted proteomics strategies of high accuracy and sensitivity, such as multiple reaction monitoring (MRM), have been set up for quantitative analysis of known protein networks. Furthermore, the conformation of proteins can be analyzed using amide hydrogen exchange (HDX) mass spectrometry, which allows the analysis of protein mechanics, protein-protein interaction interfaces and ligand-induced allosteric conformational changes.



NEWS

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Dear customers,

We are happy to announce that the core facility is functional again. Beginning with 2nd November new projects can be initiated and we are ready to take new samples. Only measurement of whole protein masses is not possible at the moment. We are working on that and post it here as soon as we fixed the problem. Please follow the link "sample submission" to get detailed instruction about filling the form of iLab Software to keep direct contact during handing over the samples to a minimum. For further informations please contact:

ms-service@zmbh.uni-heidelberg.de.


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Financial Support

ZMBH, DKFZ-ZMBH-Alliance, CellNetworks, HMLS, DKFZ, SFB1036, SFB 638, Graduiertenkolleg 1188, Transregio 83.