Contact us:
Zentrum für Molekulare Biologie der
Universität Heidelberg (ZMBH)
Im Neuenheimer Feld 282
Room 401
69120 Heidelberg, Germany
Tel.: +49-6221-54 6813
Fax: +49-6221-54 5894
ms-service@zmbh.uni-heidelberg.de
- Protein identification
from 1D and 2D-gels
Established procedures
allow the exploratory analysis of the
protein content of cells and organisms
and their temporal qualitative and
quantitative changes that accompany
development, reaction to environmental
impacts and pathophysiological
processes. Targeted proteomics
strategies of high accuracy and
sensitivity, such as multiple reaction
monitoring (MRM), have been set up for
quantitative analysis of known protein
networks. Furthermore, the conformation
of proteins can be analyzed using amide
hydrogen exchange (HDX) mass
spectrometry, which allows the analysis
of protein mechanics, protein-protein
interaction interfaces and
ligand-induced allosteric conformational
changes. |
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