Selected publications by members of the ZMBH Imaging Facility: Publications from work done at the ZMBH Imaging Facility (2018 - now):
Benesova K, Kraus FV, Carvalho RA, Lorenz H, Hoerth CH, Guenther J, Klika KD, Graf J, Diekmann L, Schank T, Christopoulos P, Hassel JC, Lorenz HM, Souto-Carneiro M. Distinct immune-effector and metabolic profile of CD8+ T cells in patients with autoimmune polyarthritis induced by therapy with immune checkpoint inhibitors. Ann Rheum Dis. 2022 Nov 10;81(12):1730-1741. doi: 10.1136/ard-2022-222451. PMID: 35922125; PMCID: PMC9664113.
Jaiswal A, Hoerth CH, Zuniga Pereira AM, Lorenz H. Improved spatial resolution by induced live cell and organelle swelling in hypotonic solutions. Sci Rep. doi: 10.1038/s41598-019-49408-2. (2019)
Avci, D. et al. The intramembrane protease SPP impacts morphology of the Endoplasmic Reticulum by triggering degradation of morphogenic proteins. J Biol Chem. doi: 10.1074/jbc.RA118.005642 (2018) [Epub ahead of print]
Uddin, B. et al. The human phosphatase CDC14A modulates primary cilium length by regulating centrosomal actin nucleation. EMBO Rep. doi: 10.15252/embr.201846544 (2018) [Epub ahead of print]
Baerenz, F. et al. Ccdc61 controls centrosomal localization of Cep170 and is required for spindle assembly and symmetry. Mol Biol Cell. doi: 10.1091/mbc.E18-02-0115 (2018) [Epub ahead of print]
Hoffmann, A. et al. Early blood-brain barrier disruption in ischemic stroke initiates multifocally around capillaries/venules. Stroke. doi: 10.1161/STROKEAHA.118.020927 (2018)
Jafarpour, A. & Lorenz, H. Cellulyzer - Automated analysis and interactive visualization/simulation of select cellular processes. arXiv:1703.02611 [physics.bio-ph] (2017)
Jafarpour, A. & Lorenz, H. Inspecting digital image integrity with InspectJ. https://github.com/ZMBH-Imaging-Facility and at https://www.youtube.com/playlist?list=PL9e7IFrONWL7_rJqVKki1Ee0FvqXRl4Ch. (2017)
Yonashiro, R. et al. The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation. Elife 5, doi:10.7554/eLife.11794 (2016)
Stockklausner, C. et al. A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition. Aging (Albany NY) 7, 911-927 (2015)
Sendra, G. H., Hoerth, C. H., Wunder, C. & Lorenz, H. 2D map projections for visualization and quantitative analysis of 3D fluorescence micrographs. Sci Rep 5, 12457, doi:10.1038/srep12457 (2015)
Meissner, C., Lorenz, H., Hehn, B. & Lemberg, M. K. Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy. Autophagy 11, 1484-1498, doi:10.1080/15548627.2015.1063763 (2015)
Kaistha, B. P. et al. PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory Pathways. Cancer Res, doi:10.1158/0008-5472.CAN-15-0216 (2015)
Werner, A. et al. SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression. Nature cell biology 15, 179-188, doi:10.1038/ncb2661 (2013)
Barenz, F. et al. The centriolar satellite protein SSX2IP promotes centrosome maturation. The Journal of cell biology 202, 81-95, doi:10.1083/jcb.201302122 (2013)
Wolf, W. et al. Yeast Ist2 recruits the endoplasmic reticulum to the plasma membrane and creates a ribosome-free membrane microcompartment. PLoS One 7, e39703, doi:10.1371/journal.pone.0039703 (2012)
Vilardi, F., Lorenz, H. & Dobberstein, B. WRB is the receptor for TRC40/Asna1-mediated insertion of tail-anchored proteins into the ER membrane. J Cell Sci 124, 1301-1307, doi:10.1242/jcs.084277 (2011)
Meissner, C., Lorenz, H., Weihofen, A., Selkoe, D. J. & Lemberg, M. K. The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking. J Neurochem 117, 856-867, doi:10.1111/j.1471-4159.2011.07253.x (2011)
Wunder, C., Lippincott-Schwartz, J. & Lorenz, H. Determining membrane protein topologies in single cells and high-throughput screening applications. Curr Protoc Cell Biol Chapter 5, Unit 5 7, doi:10.1002/0471143030.cb0507s49 (2010)
Khmelinskii, A., Keller, P. J., Lorenz, H., Schiebel, E. & Knop, M. Segregation of yeast nuclear pores. Nature 466, E1, doi:10.1038/nature09255 (2010)
Lorenz, H., Hailey, D. W., Wunder, C. & Lippincott-Schwartz, J. The fluorescence protease protection (FPP) assay to determine protein localization and membrane topology. Nature protocols 1, 276-279, doi:10.1038/nprot.2006.42 (2006)
Lorenz, H., Hailey, D. W. & Lippincott-Schwartz, J. Fluorescence protease protection of GFP chimeras to reveal protein topology and subcellular localization. Nature methods 3, 205-210, doi:10.1038/nmeth857 (2006)
Frescas, D., Mavrakis, M., Lorenz, H., Delotto, R. & Lippincott-Schwartz, J. The secretory membrane system in the Drosophila syncytial blastoderm embryo exists as functionally compartmentalized units around individual nuclei. The Journal of cell biology 173, 219-230, doi:10.1083/jcb.200601156 (2006)
2026
Llamazares-Prada M, Schwartz U, Pease DF, Pohl ST, Ackesson D, Li R, Behrendt A, Tamas R, Stammler V, Richter M, Muley T, Scherer M, Hey J, Espinet E, Heußel CP, Warth A, Schneider MA, Winter H, Herth FJ, Imbusch CD, Brors B, Benes V, Wyatt D, Jurkowski TP, Stahl HF, Plass C, Jurkowska RZ. Epigenetic dysregulation of IRF9 drives excessive interferon signaling in COPD. EMBO Mol Med. 2026 Feb 23. doi: 10.1038/s44321-026-00386-9. Epub ahead of print. PMID: 41731077.
Fuerbacher S, Doll P, Zhang J, Lange L, van den Bergh N, Zhang Y, Vitiello E, Gruen F, Sunbul M, Jaeschke A. A Near-Infrared Aptamer:Dye System For Live-Cell Super-Resolution RNA Imaging. J Am Chem Soc. 2026 Jan 21;148(2):2405-2418. doi: 10.1021/jacs.5c16419. Epub 2026 Jan 8. PMID: 41505753.
2025
Gao Q, Hofer FW, Filbeck S, Vermeulen BJA, Wuertz M, Neuner A, Kaplan C, Zezlina M, Sala C, Shin H, Gruss OJ, Schiebel E, Pfeffer S. Structural mechanisms for centrosomal recruitment and organization of the microtubule nucleator y-TuRC. Nat Commun. 2025 Mar 12;16(1):2453. doi: 10.1038/s41467-025-57729-2. PMID: 40074789; PMCID: PMC11903878.
Gleitze S, Ramírez OA, Vega-Vasquez I, Stefan E, Bengtson CP, Paula-Lima A, Bading H, Hidalgo C. Calcium release via IP3R/RyR channels contributes to the nuclear and mitochondrial Ca2+ signals elicited by neuronal stimulation. Biochem Biophys Res Commun. 2025 Mar 25;754:151445. doi: 10.1016/j.bbrc.2025.151445. Epub 2025 Feb 9. PMID: 40022811.
Jaeger S, Tittelmeier J, Dang TL, Bellande T, Redeker V, Buell AK, Hennig J, Melki R, Nussbaum-Krammer C, Bukau B, Wentink AS. Structural polymorphism of alpha-synuclein fibrils alters the pathway of Hsc70-mediated disaggregation. EMBO J. 2025 Nov;44(22):6499-6526. doi: 10.1038/s44318-025-00573-3. Epub 2025 Oct 6. PMID: 41053261; PMCID: PMC12623964.
Jin G, Campos J, Liu Y, de la Cruz BM, Zhang S, Liang M, Li K, Xie X, Sterky FH, Acuna C, Wei Z. The liprin-aRIM complex regulates the dynamic assembly of presynaptic active zones via liquid-liquid phase separation. PLoS Biol. 2025 Jun 10;23(6):e3002817. doi: 10.1371/journal.pbio.3002817. PMID: 40493522; PMCID: PMC12151379.
Ruger-Herreros C, Svoboda L, Male G, Shrivastava A, Hoepfler M, Jetzinger K, Koubek J, Kramer G, den Brave F, Mogk A, Gross DS, Bukau B. Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response. Elife. 2025 Sep 30;14:RP107157. doi: 10.7554/eLife.107157. PMID: 41025326; PMCID: PMC12483511.
Taoum A, Friede R, Thaden O, Rachynskyi O, Frank A, Wang M, Dehli F, Fuest M, Duarte Campos D. 3D Differentiation of Bone-Marrow Derived Mesenchymal Stromal Cells into the Keratocyte Lineage for Corneal Bioprinting. Adv Healthc Mater. 2025 Nov;14(28):e2405073. doi: 10.1002/adhm.202405073. Epub 2025 Jul 29. PMID: 40734361; PMCID: PMC12581885.
2024
Hung HC, Costas-Insua C, Holbrook SE, Stauffer JE, Martin PB, Mueller TA, Schroeder DG, Kigoshi-Tansho Y, Xu H, Rudolf R, Cox GA, Joazeiro CAP. Poly-alanine-tailing is a modifier of neurodegeneration caused by Listerin mutation. bioRxiv [Preprint]. 2024 Aug 24:2024.08.24.608776. doi: 10.1101/2024.08.24.608776. PMID: 39229065; PMCID: PMC11370587.
Li J, Huang K, Dibra I, Liu Y, Perrimon N, Simons M. Desaturase-dependent secretory functions of hepatocyte-like cells control systemic lipid metabolism during starvation in Drosophila. Res Sq [Preprint]. 2024 Dec 11:rs.3.rs-5566817. doi: 10.21203/rs.3.rs-5566817/v1. PMID: 39711529; PMCID: PMC11661362.
Lolicato F, Steringer JP, Saleppico R, Beyer D, Fernandez-Sobaberas J, Unger S, Klein S, Riegerová P, Wegehingel S, Mueller HM, Schmitt XJ, Kaptan S, Freund C, Hof M, Sachl R, Chlanda P, Vattulainen I, Nickel W. Disulfide bridge-dependent dimerization triggers FGF2 membrane translocation into the extracellular space. Elife. 2024 Jan 22;12:RP88579. doi: 10.7554/eLife.88579. PMID: 38252473; PMCID: PMC10945597.
Marco de la Cruz B, Campos J, Molinaro A, Xie X, Jin G, Wei Z, Acuna C, Sterky FH. Liprin-α proteins are master regulators of human presynapse assembly. Nat Neurosci. 2024 Apr;27(4):629-642. doi: 10.1038/s41593-024-01592-9. Epub 2024 Mar 12. PMID: 38472649; PMCID: PMC11001580.
Moretti-Horten DN, Peselj C, Taskin AA, Myketin L, Schulte U, Einsle O, Drepper F, Luzarowski M, Vögtle FN. Synchronized assembly of the oxidative phosphorylation system controls mitochondrial respiration in yeast. Dev Cell. 2024 Apr 22;59(8):1043-1057.e8. doi: 10.1016/j.devcel.2024.02.011. Epub 2024 Mar 19. PMID: 38508182.
Sala C, Wuertz M, Atorino ES, Neuner A, Partscht P, Hoffmann T, Eustermann S, Schiebel E. An interaction network of inner centriole proteins organised by POC1A-POC1B heterodimer crosslinks ensures centriolar integrity. Nat Commun. 2024 Nov 14;15(1):9857. doi: 10.1038/s41467-024-54247-5. PMID: 39543170; PMCID: PMC11564547.
Tetzlaff SK, Reyhan E, Layer N, Bengtson CP, Heuer A, Schroers J, Faymonville AJ, Langeroudi AP, Drewa N, Keifert E, Wagner J, Soyka SJ, Schubert MC, Sivapalan N, Pramatarov RL, Buchert V, Wageringel T, Grabis E, Wissmann N, Alhalabi OT, Botz M, Bojcevski J, Campos J, Boztepe B, Scheck JG, Conic SH, Puschhof MC, Villa G, Drexler R, Zghaibeh Y, Hausmann F, Haenzelmann S, Karreman MA, Kurz FT, Schroeter M, Thier M, Suwala AK, Forsberg-Nilsson K, Acuna C, Saez-Rodriguez J, Abdollahi A, Sahm F, Breckwoldt MO, Suchorska B, Ricklefs FL, Heiland DH, Venkataramani V. Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing. Cell. 2025 Jan 23;188(2):390-411.e36. doi: 10.1016/j.cell.2024.11.002. Epub 2024 Dec 6. PMID: 39644898.
Zoltsman G, Dang TL, Kuchersky M, Faust O, Silva MS, Ilani T, Wentink AS, Bukau B, Rosenzweig R. A unique chaperoning mechanism in class A JDPs recognizes and stabilizes mutant p53. Mol Cell. 2024 Apr 18;84(8):1512-1526.e9. doi: 10.1016/j.molcel.2024.02.018. Epub 2024 Mar 19. PMID: 38508184.
2023
Denolly S, Stukalov A, Barayeu U, Rosinski AN, Kritsiligkou P, Joecks S, Dick TP, Pichlmair A, Bartenschlager R. Zika virus remodelled ER membranes contain proviral factors involved in redox and methylation pathways. Nat Commun. 2023 Dec 5;14(1):8045. doi: 10.1038/s41467-023-43665-6. PMID: 38052817; PMCID: PMC10698153.
Jawed A, Ho CT, Grousl T, Shrivastava A, Ruppert T, Bukau B, Mogk A. Balanced activities of Hsp70 and the ubiquitin proteasome system underlie cellular protein homeostasis. Front Mol Biosci. 2023 Jan 4;9:1106477. doi: 10.3389/fmolb.2022.1106477. PMID: 36660429; PMCID: PMC9845930.
Koch J, Xin Q, Obr M, Schaefer A, Rolfs N, Anagho HA, Kudulyte A, Woltereck L, Kummer S, Campos J, Uckeley ZM, Bell-Sakyi L, Kräusslich HG, Schur FK, Acuna C, Lozach PY. The phenuivirus Toscana virus makes an atypical use of vacuolar acidity to enter host cells. PLoS Pathog. 2023 Aug 14;19(8):e1011562. doi: 10.1371/journal.ppat.1011562. PMID: 37578957; PMCID: PMC10449198.
Partscht P, Simon A, Chen NP, Erhardt S, Schiebel E. The HIPK2/CDC14B-MeCP2 axis enhances the spindle assembly checkpoint block by promoting cyclin B translation. Sci Adv. 2023 Jan 20;9(3):eadd6982. doi: 10.1126/sciadv.add6982. Epub 2023 Jan 20. PMID: 36662865; PMCID: PMC9858502.
Schwartz U, Llamazares Prada M, Pohl ST, Richter M, Tamas R, Schuler M, Keller C, Mijosek V, Muley T, Schneider MA, Quast K, Hey J, Heußel CP, Warth A, Winter H, Serçin Ö, Karmouty-Quintana H, Jyothula SS, Patel MK, Herth F, Koch I, Petrosino G, Titimeaua A, Mardin BR, Weichenhan D, Jurkowski TP, Imbusch CD, Brors B, Benes V, Jung B, Wyatt D, Stahl HF, Plass C, Jurkowska RZ. High-resolution transcriptomic and epigenetic profiling identifies novel regulators of COPD. EMBO J. 2023 Jun 15;42(12):e111272. doi: 10.15252/embj.2022111272. Epub 2023 May 5. PMID: 37143403; PMCID: PMC10267701.
2022
Benesova K, Kraus FV, Carvalho RA, Lorenz H, Hoerth CH, Guenther J, Klika KD, Graf J, Diekmann L, Schank T, Christopoulos P, Hassel JC, Lorenz HM, Souto-Carneiro M. Distinct immune-effector and metabolic profile of CD8+ T cells in patients with autoimmune polyarthritis induced by therapy with immune checkpoint inhibitors. Ann Rheum Dis. 2022 Aug 3;81(12):1730-41. doi: 10.1136/ard-2022-222451. Epub ahead of print. PMID: 35922125; PMCID: PMC9664113.
Bock J, Kuehnle N, Knopf JD, Landscheidt N, Lee JG, Ye Y, Lemberg MK. Rhomboid protease RHBDL4 promotes retrotranslocation of aggregation-prone proteins for degradation. Cell Rep. 2022 Aug 9;40(6):111175. doi: 10.1016/j.celrep.2022.111175. PMID: 35947953; PMCID: PMC9437926.
Dang H, Martin-Villalba A, Schiebel E. Centrosome linker protein C-Nap1 maintains stem cells in mouse testes. EMBO Rep. 2022 Jul 5;23(7):e53805. doi: 10.15252/embr.202153805. Epub 2022 May 23. PMID: 35599622; PMCID: PMC9253759.
Golchoubian B, Brunner A, Bragulat-Teixidor H, Neuner A, Akarlar BA, Ozlu N, Schlaitz AL. Reticulon-like REEP4 at the inner nuclear membrane promotes nuclear pore complex formation. J Cell Biol. 2022 Feb 7;221(2):e202101049. doi: 10.1083/jcb.202101049. Epub 2021 Dec 7. PMID: 34874453; PMCID: PMC8656412.
Jawed A, Ho CT, Grousl T, Shrivastava A, Ruppert T, Bukau B, Mogk A. Balanced activities of Hsp70 and the ubiquitin proteasome system underlie cellular protein homeostasis. Front Mol Biosci. 2023 Jan 4;9:1106477. doi: 10.3389/fmolb.2022.1106477. PMID: 36660429; PMCID: PMC9845930.
Kanamaru T, Neuner A, Kurtulmus B, Pereira G. Balancing the length of the distal tip by septins is key for stability and signalling function of primary cilia. EMBO J. 2022 Jan 4;41(1):e108843. doi: 10.15252/embj.2021108843. Epub 2021 Nov 22. PMID: 34981518; PMCID: PMC8724769.
Karasu OR, Neuner A, Atorino ES, Pereira G, Schiebel E. The central scaffold protein CEP350 coordinates centriole length, stability, and maturation. J Cell Biol. 2022 Dec 5;221(12):e202203081. doi: 10.1083/jcb.202203081. Epub 2022 Oct 31. PMID: 36315013; PMCID: PMC9623370.
Marchetti M, Zhang C, Edgar BA. An improved organ explant culture method reveals stem cell lineage dynamics in the adult Drosophila intestine. Elife. 2022 Aug 25;11:e76010. doi: 10.7554/eLife.76010. PMID: 36005292; PMCID: PMC9578704.
Perez-Marti A, Ramakrishnan S, Li J, Dugourd A, Molenaar MR, De La Motte LR, Grand K, Mansouri A, Parisot M, Lienkamp SS, Saez-Rodriguez J, Simons M. Reducing lipid bilayer stress by monounsaturated fatty acids protects renal proximal tubules in diabetes. Elife. 2022 May 12;11:e74391. doi: 10.7554/eLife.74391. PMID: 35550039; PMCID: PMC9154741.
Peselj C, Ebrahimi M, Broeskamp F, Prokisch S, Habernig L, Alvarez-Guerra I, Kohler V, Voegtle FN, Buettner S. Sterol Metabolism Differentially Contributes to Maintenance and Exit of Quiescence. Front Cell Dev Biol. 2022 Feb 14;10:788472. doi: 10.3389/fcell.2022.788472. PMID: 35237594; PMCID: PMC8882848.
Shrivastava A, Sandhof CA, Reinle K, Jawed A, Ruger-Herreros C, Schwarz D, Creamer D, Nussbaum-Krammer C, Mogk A, Bukau B. The cytoprotective sequestration activity of small heat shock proteins is evolutionarily conserved. J Cell Biol. 2022 Oct 3;221(10):e202202149. doi: 10.1083/jcb.202202149. Epub 2022 Sep 7. PMID: 36069810; PMCID: PMC9458469.
Tittelmeier J, Druffel-Augustin S, Alik A, Melki R, Nussbaum-Krammer C. Dissecting aggregation and seeding dynamics of a-Syn polymorphs using the phasor approach to FLIM. Commun Biol. 2022 Dec 8;5(1):1345. doi: 10.1038/s42003-022-04289-6. PMID: 36477485; PMCID: PMC9729209.
2021
Barysch SV, Stankovic-Valentin N, Miedema T, Karaca S, Doppel J, Nait Achour T, Vasudeva A, Wolf L, Sticht C, Urlaub H, Melchior F. Transient deSUMOylation of IRF2BP proteins controls early transcription in EGFR signaling. EMBO Rep. 2021 Mar 3;22(3):e49651. doi: 10.15252/embr.201949651. Epub 2021 Jan 22. PMID: 33480129; PMCID: PMC7926235.
Benfatto, S., Sercin, O., Dejure, F.R. et al. Uncovering cancer vulnerabilities by machine learning prediction of synthetic lethality. Mol Cancer 20, 111 (2021). https://doi.org/10.1186/s12943-021-01405-8
Falk F, Kamanyi Marucha K, Clayton C. The EIF4E1-4EIP cap-binding complex of Trypanosoma brucei interacts with the terminal uridylyl transferase TUT3. PLoS One. 2021 Nov 22;16(11):e0258903. doi: 10.1371/journal.pone.0258903. PMID: 34807934; PMCID: PMC8608314.
Kritsiligkou P, Shen TK, Dick TP. A comparison of Prx- and OxyR-based H2O2 probes expressed in S.cerevisiae. J Biol Chem. 2021 Jul;297(1):100866. doi: 10.1016/j.jbc.2021.100866. Epub 2021 Jun 9. PMID: 34118234; PMCID: PMC8274284.
Llamazares-Prada M, Espinet E, Mijosek V, Schwartz U, Lutsik P, Tamas R, Richter M, Behrendt A, Pohl ST, Benz NP, Muley T, Warth A, Heußel CP, Winter H, Landry JJM, Herth FJ, Mertens TC, Karmouty-Quintana H, Koch I, Benes V, Korbel JO, Waszak SM, Trumpp A, Wyatt DM, Stahl HF, Plass C, Jurkowska RZ. Versatile workflow for cell type-resolved transcriptional and epigenetic profiles from cryopreserved human lung. JCI Insight. 2021 Mar 22;6(6):e140443. doi: 10.1172/jci.insight.140443. PMID: 33630765; PMCID: PMC8026197.
Norell S, Ortiz J, Lechner J. Slk19 enhances cross-linking of microtubules by Ase1 and Stu1. Mol Biol Cell. 2021 Nov 1;32(21):ar22. doi: 10.1091/mbc.E21-05-0279. Epub 2021 Sep 8. PMID: 34495712; PMCID: PMC8693956.
Papagiannidis D, Bircham PW, Luechtenborg C, Pajonk O, Ruffini G, Bruegger B, Schuck S. Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex. EMBO J. 2021 Nov 15;40(22):e107958. doi: 10.15252/embj.2021107958. Epub 2021 Oct 6. PMID: 34617598; PMCID: PMC8591542.
Queiroz MG, Elsztein C, Strahl S, de Morais Junior MA. The Saccharomyces cerevisiae Ncw2 protein works on the chitin/β-glucan organisation of the cell wall. Antonie Van Leeuwenhoek. 2021 Jul;114(7):1141-1153. doi: 10.1007/s10482-021-01584-w. Epub 2021 May 4. PMID: 33945065.
Schweiggert J, Habeck G, Hess S, Mikus F, Beloshistov R, Meese K, Hata S, Knobeloch KP, Melchior F. SCFFbxw5 targets kinesin-13 proteins to facilitate ciliogenesis. EMBO J. 2021 Sep 15;40(18):e107735. doi: 10.15252/embj.2021107735. Epub 2021 Aug 9. PMID: 34368969; PMCID: PMC8441365.
Theile L, Li X, Dang H, Mersch D, Anders S, Schiebel E. Centrosome linker diversity and its function in centrosome clustering and mitotic spindle formation. EMBO J. 2023 Jul 4:e109738. doi: 10.15252/embj.2021109738. Epub ahead of print. PMID: 37401899.
2020
Ahmed SMH, Maldera JA, Krunic D, Paiva-Silva GO, Pénalva C, Teleman AA, Edgar BA. Fitness trade-offs incurred by ovary-to-gut steroid signalling in Drosophila. Nature. 2020 Aug;584(7821):415-419. doi: 10.1038/s41586-020-2462-y. Epub 2020 Jul 8. PMID: 32641829; PMCID: PMC7442704.
Babel H, Naranjo-Meneses P, Trauth S, Schulmeister S, Malengo G, Sourjik V, Bischofs IB. Ratiometric population sensing by a pump-probe signaling system in Bacillus subtilis. Nat Commun. 2020 Mar 4;11(1):1176. doi: 10.1038/s41467-020-14840-w. PMID: 32132526; PMCID: PMC7055314.
Bajak K, Leiss K, Clayton C, Erben E. A potential role for a novel ZC3H5 complex in regulating mRNA translation in Trypanosoma brucei. J Biol Chem. 2020 Oct 16;295(42):14291-14304. doi: 10.1074/jbc.RA120.014346. Epub 2020 Aug 5. PMID: 32763974; PMCID: PMC7573263.
Bajak K, Leiss K, Clayton CE, Erben E. The endoplasmic reticulum-associated mRNA-binding proteins ERBP1 and ERBP2 interact in bloodstream-form Trypanosoma brucei. PeerJ. 2020 Feb 14;8:e8388. doi: 10.7717/peerj.8388. PMID: 32095321; PMCID: PMC7025706.
Fueller J, Herbst K, Meurer M, Gubicza K, Kurtulmus B, Knopf JD, Kirrmaier D, Buchmuller BC, Pereira G, Lemberg MK, Knop M. CRISPR-Cas12a-assisted PCR tagging of mammalian genes. J Cell Biol. 2020 Jun 1;219(6):e201910210. doi: 10.1083/jcb.201910210. PMID: 32406907; PMCID: PMC7265327.
Haneke K, Schott J, Lindner D, Hollensen AK, Damgaard CK, Mongis C, Knop M, Palm W, Ruggieri A, Stoecklin G. CDK1 couples proliferation with protein synthesis. J Cell Biol. 2020 Mar 2;219(3):e201906147. doi: 10.1083/jcb.201906147. PMID: 32040547; PMCID: PMC7054999.
Melo do Nascimento L, Terrao M, Marucha KK, Liu B, Egler F, Clayton C. The RNA-associated proteins MKT1 and MKT1L form alternative PBP1-containing complexes in Trypanosoma brucei. J Biol Chem. 2020 Aug 7;295(32):10940-10955. doi: 10.1074/jbc.RA120.013306. Epub 2020 Jun 12. PMID: 32532821; PMCID: PMC7415969.
Sandhof CA, Hoppe SO, Druffel-Augustin S, Gallrein C, Kirstein J, Voisine C, Nussbaum-Krammer C. Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading. Autophagy. 2020 May;16(5):878-899. doi: 10.1080/15548627.2019.1643657. Epub 2019 Jul 29. PMID: 31354022; PMCID: PMC7144869.
Schaefer JA, Schessner JP, Bircham PW, Tsuji T, Funaya C, Pajonk O, Schaeff K, Ruffini G, Papagiannidis D, Knop M, Fujimoto T, Schuck S. ESCRT machinery mediates selective microautophagy of endoplasmic reticulum in yeast. EMBO J. 2020 Jan 15;39(2):e102586. doi: 10.15252/embj.2019102586. Epub 2019 Dec 5. PMID: 31802527; PMCID: PMC6960443.
Suchanek VM, Esteban-Lopez M, Colin R, Besharova O, Fritz K, Sourjik V. Chemotaxis and cyclic-di-GMP signalling control surface attachment of Escherichia coli. Mol Microbiol. 2020 Apr;113(4):728-739. doi: 10.1111/mmi.14438. Epub 2019 Dec 16. PMID: 31793092.
Tittelmeier J, Sandhof CA, Ries HM, Druffel-Augustin S, Mogk A, Bukau B, Nussbaum-Krammer C. The HSP110/HSP70 disaggregation system generates spreading-competent toxic alpha-synuclein species. EMBO J. 2020 Jul 1;39(13):e103954. doi: 10.15252/embj.2019103954. Epub 2020 May 25. PMID: 32449565; PMCID: PMC7327497.
2019
Avci D, Malchus NS, Heidasch R, Lorenz H, Richter K, Nessling M, Lemberg MK. The intramembrane protease SPP impacts morphology of the endoplasmic reticulum by triggering degradation of morphogenic proteins. J Biol Chem. 2019 Feb 22;294(8):2786-2800. doi: 10.1074/jbc.RA118.005642. Epub 2018 Dec 21. PMID: 30578301; PMCID: PMC6393608.
Constantinou I, Jendrusch M, Aspert T, Goerlitz F, Schulze A, Charvin G, Knop M. Self-Learning Microfluidic Platform for Single-Cell Imaging and Classification in Flow. Micromachines (Basel). 2019 May 9;10(5):311. doi: 10.3390/mi10050311. PMID: 31075890; PMCID: PMC6563144.
Dimou E, Cosentino K, Platonova E, Ros U, Sadeghi M, Kashyap P, Katsinelos T, Wegehingel S, Noe F, Garcia-Saez AJ, Ewers H, Nickel W. Single event visualization of unconventional secretion of FGF2. J Cell Biol. 2019 Feb 4;218(2):683-699. doi: 10.1083/jcb.201802008. Epub 2018 Nov 23. PMID: 30470711; PMCID: PMC6363455.
Jaiswal A, Hoerth CH, Zuniga Pereira AM, Lorenz H. Improved spatial resolution by induced live cell and organelle swelling in hypotonic solutions. Sci Rep. doi: 10.1038/s41598-019-49408-2. (2019)
Kumar D, Golchoubian B, Belevich I, Jokitalo E, Schlaitz AL. REEP3 and REEP4 determine the tubular morphology of the endoplasmic reticulum during mitosis. Mol Biol Cell. 2019 Jun 1;30(12):1377-1389. doi: 10.1091/mbc.E18-11-0698. Epub 2019 Apr 17. PMID: 30995177; PMCID: PMC6724692.
Lafarga V, Sung HM, Haneke K, Roessig L, Pauleau AL, Bruer M, Rodriguez-Acebes S, Lopez-Contreras AJ, Gruss OJ, Erhardt S, Mendez J, Fernandez-Capetillo O, Stoecklin G. TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress. EMBO Rep. 2019 Jan;20(1):e46224. doi: 10.15252/embr.201846224. Epub 2018 Dec 11. PMID: 30538118; PMCID: PMC6322364.
Patel PH, Pénalva C, Kardorff M, Roca M, Pavlovic B, Thiel A, Teleman AA, Edgar BA. Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut. Nat Commun. 2019 Sep 25;10(1):4365. doi: 10.1038/s41467-019-12336-w. PMID: 31554796; PMCID: PMC6761285.
Pauleau AL, Bergner A, Kajtez J, Erhardt S. The checkpoint protein Zw10 connects CAL1-dependent CENP-A centromeric loading and mitosis duration in Drosophila cells. PLoS Genet. 2019 Sep 25;15(9):e1008380. doi: 10.1371/journal.pgen.1008380. PMID: 31553715; PMCID: PMC6779278.
Schmidt RM, Schessner JP, Borner GH, Schuck S. The proteasome biogenesis regulator Rpn4 cooperates with the unfolded protein response to promote ER stress resistance. Elife. 2019 Mar 13;8:e43244. doi: 10.7554/eLife.43244. PMID: 30865586; PMCID: PMC6415940.
Yokoyama H, Moreno-Andres D, Astrinidis SA, Hao Y, Weberruss M, Schellhaus AK, Lue H, Haramoto Y, Gruss OJ, Antonin W. Chromosome alignment maintenance requires the MAP RECQL4, mutated in the Rothmund-Thomson syndrome. Life Sci Alliance. 2019 Feb 4;2(1):e201800120. doi: 10.26508/lsa.201800120. PMID: 30718377; PMCID: PMC6362308.
2018
Alborzinia H, Ignashkova TI, Dejure FR, Gendarme M, Theobald J, Woelfl S, Lindemann RK, Reiling JH. Golgi stress mediates redox imbalance and ferroptosis in human cells. Commun Biol. 2018 Nov 28;1:210. doi: 10.1038/s42003-018-0212-6. PMID: 30511023; PMCID: PMC6262011.
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Begolo D, Vincent IM, Giordani F, Pöhner I, Witty MJ, Rowan TG, Bengaly Z, Gillingwater K, Freund Y, Wade RC, Barrett MP, Clayton C. The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing. PLoS Pathog. 2018 Sep 25;14(9):e1007315. doi: 10.1371/journal.ppat.1007315. PMID: 30252911; PMCID: PMC6173450.
Garcia Del Arco A, Edgar BA, Erhardt S. In Vivo Analysis of Centromeric Proteins Reveals a Stem Cell-Specific Asymmetry and an Essential Role in Differentiated, Non-proliferating Cells. Cell Rep. 2018 Feb 20;22(8):1982-1993. doi: 10.1016/j.celrep.2018.01.079. PMID: 29466727.
Grousl T, Ungelenk S, Miller S, Ho CT, Khokhrina M, Mayer MP, Bukau B, Mogk A. A prion-like domain in Hsp42 drives chaperone-facilitated aggregation of misfolded proteins. J Cell Biol. 2018 Apr 2;217(4):1269-1285. doi: 10.1083/jcb.201708116. Epub 2018 Jan 23. PMID: 29362223; PMCID: PMC5881502.
Hoffmann, A. et al. Early blood-brain barrier disruption in ischemic stroke initiates multifocally around capillaries/venules. Stroke. doi: 10.1161/STROKEAHA.118.020927 (2018)
Shiber A, Doering K, Friedrich U, Klann K, Merker D, Zedan M, Tippmann F, Kramer G, Bukau B. Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling. Nature. 2018 Sep;561(7722):268-272. doi: 10.1038/s41586-018-0462-y. Epub 2018 Aug 29. PMID: 30158700; PMCID: PMC6372068.
Uddin, B. et al. The human phosphatase CDC14A modulates primary cilium length by regulating centrosomal actin nucleation. EMBO Rep. doi: 10.15252/embr.201846544 (2018) [Epub ahead of print]
