ZMBH - Open Positions

Scientific Job Openings

Postdoctoral and PhD student positions (3 years, with possible extensions) are available immediately in the evolutionary genomics group of Henrik Kaessmann at Heidelberg University. Applications will be reviewed on a rolling basis until the positions are filled.

We are seeking highly qualified, motivated, and enthusiastic candidates with a keen interest in evolutionary questions. For the postdoctoral position, a strong background and hands-on experience in experimental molecular and genomics approaches are required; additional experience in computational/bioinformatics analyses is highly welcome. For the doctoral position, we welcome candidates with a passion and aptitude for experimental molecular/genomics work, computational/bioinformatics analyses, or both. Projects in our lab usually combine experimental and computational components, with the relative emphasis tailored to the specific project and the candidate’s interests and expertise.

Our lab investigates a broad range of questions related to the origins and molecular evolution of organs in mammals and other vertebrates and the underlying genomic changes, with a particular focus on the evolution of gene expression and its regulatory basis (see home.kaessmannlab.org and zmbh.uni-heidelberg.de/kaessmann for more information). As part of this research, we have generated extensive comparative genomics datasets (e.g., single-cell RNA-seq and ATAC-seq) across species, based on samples from our unique organ collections, and analyzed them using state-of-the-art bioinformatics approaches, increasingly incorporating AI and deep learning (see, e.g., Sarropoulos et al., Science 2026). This work has provided insights into the origins and functional evolution of protein-coding genes, alternative splicing, long noncoding RNAs, microRNAs, and sex chromosomes across organs and species, as well as their phenotypic implications.

We currently offer a range of possible projects addressing the evolution of gene expression and its regulatory basis across expression layers, organs, and species in mammals and other vertebrates. These projects will combine the generation of unique new datasets using cutting-edge experimental approaches (e.g., long-read spatial transcriptomics) across diverse organs, from the brain to the gonads, with state-of-the-art computational and deep-learning approaches. Projects may also include detailed molecular and functional characterization of particularly exciting candidate evolutionary changes using organoid and mouse models, CRISPR-based approaches, and synthetic genomics, supported by the expertise and infrastructure of our local Center for Synthetic Genomics (www.syn-gen.de). Specific projects will be developed together with the successful candidates based on their individual interests, expertise, and skills.

In our lab, we place great importance on a collaborative, supportive, and positive team spirit. Many of our projects are driven by small, closely interacting teams of experimental and computational researchers who combine complementary expertise and work together enthusiastically. We also greatly value the diverse cultural and international backgrounds of our lab members, which contribute to an open and enriching research environment.

The working language of our institute is English, and its members form a highly international community. The ZMBH is located in Heidelberg, a picturesque and vibrant international city on the Neckar River and at the edge of the Odenwald forest. Heidelberg offers an exceptionally stimulating and collaborative research environment, with the European Molecular Biology Laboratory (EMBL), German Cancer Research Center (DKFZ), Heidelberg Institute for Theoretical Studies (HITS), and Max Planck Institute for Medical Research located in close proximity to the University.

For more information about our group and the institute more generally, please visit our website at the ZMBH (http://www.zmbh.uni-heidelberg.de/Kaessmann/).

Please submit a CV, a statement of research interests, and the names and contact details of three references to Henrik Kaessmann (h.kaessmann@zmbh.uni-heidelberg.de).

For a collaborative project within the Cluster of Excellence 3D Materials Made to Order (3DMM2O). Our cluster combines the competencies of two Universities of Excellence, Heidelberg University and Karlsruhe Institute of Technology, to advance 3D Additive Manufacturing to the next level. 

Xolography offers a powerful new approach for fabricating in vitro vascularized tissue models. Unlike traditional layer-by-layer bioprinting, xolographic biofabrication enables true volumetric printing by intersecting light fields to generate entire 3D constructs within seconds. This rapid, contact-free process minimizes mechanical stress on encapsulated cells and allows the creation of intricate, perfusable vascular networks with high spatial resolution. Developing reliable vascularized tissue models is essential for advancing tissue engineering, disease modelling, and drug testing, as vascularization is key to maintaining cell viability and mimicking physiological function.

The Duarte Campos Lab investigates biofabrication technologies and biomaterials to engineer tissues and organs, and to understand their effects on the structure and function of living systems.

Your tasks will be to develop and characterize a vascularized in vitro tissue model. The work will involve a variety of techniques including but not limited to:

• natural and synthetic bioink preparation and handling; 
• 2D and 3D cell culture of primary human cells and cell lines 
• Xolographic fabrication of in vitro tissue models, including refining of printing parameters 
• Tune bioink stiffness and measure it with a nanoindenter 
• histological and immunofluorescence staining, two-photon imaging, qPCR 

Your profile:

• Master degree in Biomedical Engineering, Materials Science, Chemistry, Bioengineering or related disciplines

• Previous experience in hydrogel handling, 3D (bio)printing, microscopy, cell culture, and/or microfluidic systems are preferred

• Excellent achievements and English skills

• Motivation to work in an international environment as part of a team

 We offer an international and attractive work environment within the Duarte Campos Lab at the ZMBH and, as member of the 3DMM2O, you will have full access to modern state of-the-art infrastructure both at Heidelberg University and Karlsruhe Institute of Technology. The salary is based on TV-L scale (E13). The position is to be filled with 29,625 hours/week (75%) for two years, with the possibility of extension. The position is available to start in April 2026.

Applications should be sent to Prof. Daniela Duarte Campos (dcampos@uni-heidelberg.de) in one  single PDF-file that includes a letter of motivation, CV, copy of transcripts and name of 2-3 referees. We ask for your understanding that application documents received by post will not be returned.

Closing date for applications: November 28, 2025

Heidelberg University stands for equal opportunities and diversity. Qualified female candidates are especially invited to apply. Disabled persons will be given preference if they are equally qualified. Information on the application process and the collection of personal data is available at www.uni-heidelberg.de/stellenmarkt.

Master Available “Centriole Duplication”

ZMBH, Heidelberg University

Are you passionate about cell biology and eager to explore the fascinating world of centrioles? Prof. Elmar Schiebel at the Centre for Molecular Biology (ZMBH) at Heidelberg University invites applications for a Master position focusing on centriole duplication.

About the Position:
The successful candidate will join Prof. Elmar Schiebel’s research group, renowned for its work on gamma-tubulin, centrioles and centrosome function. This Master project will investigate the molecular mechanisms underlying centriole duplication. The research will combine advanced microscopy techniques, biochemistry, and genetic tools to unravel the complexities of centriole assembly and function. The Master student will be supported by a Hiwi contract of ca. 500 € per months.

How to Apply:
Interested candidates should send their application, including a CV, cover letter, and contact information for two references, to Prof. Elmar Schiebel at schiebel.elmar@zmbh.uni-heidelberg.de.

Relevant recent publications:
1          Liu, P. et al. Insights into the assembly and activation of the microtubule nucleator gamma-TuRC. Nature 578, 467-471 (2020). https://doi.org:10.1038/s41586-019-1896-6
2          Würtz, M. et al. Modular assembly of the principal microtubule nucleator γ-TuRC. Nat Comm 473, doi: 10.1038/s41467-41022-28079-41460 (2022).
3          Karasu, O. R., Neuner, A., Atorino, E. S., Pereira, G. & Schiebel, E. The central scaffold protein CEP350 coordinates centriole length, stability, and maturation. J Cell Biol 221 (2022). https://doi.org:10.1083/jcb.202203081
4          Gao, Q. et al. The structure of the gamma-TuRC at the microtubule minus end - not just one solution. Bioessays, e2400117 (2024). https://doi.org:10.1002/bies.202400117
5          Vermeulen, B. J. et al. gamma-TuRC asymmetry induces local protofilament mismatch at the RanGTP-stimulated microtubule minus end. EMBO J (2024). https://doi.org:10.1038/s44318-024-00087-4

Non-Scientific Job Openings

Additional positions for research assistants and non-scientific personnel are also regularly published on the pages of the University's central job market:

Central job market of the University