ZMBH - Open Positions

Scientific Job Openings

in Bioengineering / Systems Biology and Yeast and Mammalian Cell Engineering (full-time)

Center for Molecular Biology of Heidelberg University (ZMBH), Heidelberg, Germany

Applications are invited for two postdoctoral positions in a collaborative project between the laboratories of Prof Dr. Nora Vögtle and Prof. Dr. Michael Knop at the Center for Molecular Biology of Heidelberg University (ZMBH), Heidelberg, Germany.

The project will combine systems biology, bioengineering, and synthetic genomics approaches, along with quantitative cell biology and biochemical techniques, to develop and interrogate biological design principles across eukaryotic systems. A central goal is to use yeast as a genetically tractable model system, followed by work in mammalian models, to establish concepts and tools that can be extended toward translational applications and, in the longer term, gene-therapy-oriented strategies.

We seek highly motivated, creative, and collaborative candidates with a strong background in molecular biology, preferably complemented by experience in one or more of the following areas:

• Yeast genetics and/or yeast cell biology
• Systems biology or quantitative biology, preferably using yeast
• Genome engineering / synthetic biology, yeast and/or mammalian
• Cell biology, microscopy, and biochemical approaches
• Functional genomics and computational data analysis, including AI

The positions are particularly well suited for applicants who are excited to work at the interface of fundamental molecular cell biology and biological engineering, and who are interested in using their fundamental knowledge in basic cell function to engage creative new concepts of biological engineering to translate mechanistic insight from model organisms, in particular yeast, into more complex cellular systems.

Successful candidates will join a highly interactive research environment at ZMBH. They will work within a collaborative setting that bridges all levels, from fundamental molecular biology to clinical applications.

Candidates should hold a PhD in molecular biology, cell biology, biochemistry, genetics, bioengineering, or a related discipline by the start date. Evidence of scientific productivity, independence, and enthusiasm for interdisciplinary research is expected. Excellent communication skills in English are required.

This job is part of an Advanced Research + Invention Agency-funded project, subject to contract negotiations.

To apply, please send:

• A cover letter outlining research interests and motivation
• A curriculum vitae
• A summary of previous research achievements
• Contact details for 2-3 referees
  

Location: ZMBH, Heidelberg University, Heidelberg, Germany

Start date: negotiable, as early as June 2026 is possible

Duration: fixed-term, minimum 2 years, with details to be specified according to funding and university regulations

Applications should be sent by May 15th, 2026 in one PDF file by email to Center SynGen (office-syngen@zmbh.uni-heidelberg.de) on behalf of Nora Vögtle and Michael Knop.

Heidelberg University stands for equal opportunities and diversity. Qualified female candidates are especially invited to apply. Persons with severe disabilities will be given preference if they are equally qualified. Information on job advertisements and the collection of personal data is available at www.uni-heidelberg.de/en/job-market.

For a collaborative project within the Cluster of Excellence 3D Materials Made to Order (3DMM2O). Our cluster combines the competencies of two Universities of Excellence, Heidelberg University and Karlsruhe Institute of Technology, to advance 3D Additive Manufacturing to the next level. 

Xolography offers a powerful new approach for fabricating in vitro vascularized tissue models. Unlike traditional layer-by-layer bioprinting, xolographic biofabrication enables true volumetric printing by intersecting light fields to generate entire 3D constructs within seconds. This rapid, contact-free process minimizes mechanical stress on encapsulated cells and allows the creation of intricate, perfusable vascular networks with high spatial resolution. Developing reliable vascularized tissue models is essential for advancing tissue engineering, disease modelling, and drug testing, as vascularization is key to maintaining cell viability and mimicking physiological function.

The Duarte Campos Lab investigates biofabrication technologies and biomaterials to engineer tissues and organs, and to understand their effects on the structure and function of living systems.

Your tasks will be to develop and characterize a vascularized in vitro tissue model. The work will involve a variety of techniques including but not limited to:

• natural and synthetic bioink preparation and handling; 
• 2D and 3D cell culture of primary human cells and cell lines 
• Xolographic fabrication of in vitro tissue models, including refining of printing parameters 
• Tune bioink stiffness and measure it with a nanoindenter 
• histological and immunofluorescence staining, two-photon imaging, qPCR 

Your profile:

• Master degree in Biomedical Engineering, Materials Science, Chemistry, Bioengineering or related disciplines

• Previous experience in hydrogel handling, 3D (bio)printing, microscopy, cell culture, and/or microfluidic systems are preferred

• Excellent achievements and English skills

• Motivation to work in an international environment as part of a team

 We offer an international and attractive work environment within the Duarte Campos Lab at the ZMBH and, as member of the 3DMM2O, you will have full access to modern state of-the-art infrastructure both at Heidelberg University and Karlsruhe Institute of Technology. The salary is based on TV-L scale (E13). The position is to be filled with 29,625 hours/week (75%) for two years, with the possibility of extension. The position is available to start in April 2026.

Applications should be sent to Prof. Daniela Duarte Campos (dcampos@uni-heidelberg.de) in one  single PDF-file that includes a letter of motivation, CV, copy of transcripts and name of 2-3 referees. We ask for your understanding that application documents received by post will not be returned.

Closing date for applications: November 28, 2025

Heidelberg University stands for equal opportunities and diversity. Qualified female candidates are especially invited to apply. Disabled persons will be given preference if they are equally qualified. Information on the application process and the collection of personal data is available at www.uni-heidelberg.de/stellenmarkt.

Master Available “Centriole Duplication”

ZMBH, Heidelberg University

Are you passionate about cell biology and eager to explore the fascinating world of centrioles? Prof. Elmar Schiebel at the Centre for Molecular Biology (ZMBH) at Heidelberg University invites applications for a Master position focusing on centriole duplication.

About the Position:
The successful candidate will join Prof. Elmar Schiebel’s research group, renowned for its work on gamma-tubulin, centrioles and centrosome function. This Master project will investigate the molecular mechanisms underlying centriole duplication. The research will combine advanced microscopy techniques, biochemistry, and genetic tools to unravel the complexities of centriole assembly and function. The Master student will be supported by a Hiwi contract of ca. 500 € per months.

How to Apply:
Interested candidates should send their application, including a CV, cover letter, and contact information for two references, to Prof. Elmar Schiebel at schiebel.elmar@zmbh.uni-heidelberg.de.

Relevant recent publications:
1          Liu, P. et al. Insights into the assembly and activation of the microtubule nucleator gamma-TuRC. Nature 578, 467-471 (2020). https://doi.org:10.1038/s41586-019-1896-6
2          Würtz, M. et al. Modular assembly of the principal microtubule nucleator γ-TuRC. Nat Comm 473, doi: 10.1038/s41467-41022-28079-41460 (2022).
3          Karasu, O. R., Neuner, A., Atorino, E. S., Pereira, G. & Schiebel, E. The central scaffold protein CEP350 coordinates centriole length, stability, and maturation. J Cell Biol 221 (2022). https://doi.org:10.1083/jcb.202203081
4          Gao, Q. et al. The structure of the gamma-TuRC at the microtubule minus end - not just one solution. Bioessays, e2400117 (2024). https://doi.org:10.1002/bies.202400117
5          Vermeulen, B. J. et al. gamma-TuRC asymmetry induces local protofilament mismatch at the RanGTP-stimulated microtubule minus end. EMBO J (2024). https://doi.org:10.1038/s44318-024-00087-4

Non-Scientific Job Openings

Additional positions for research assistants and non-scientific personnel are also regularly published on the pages of the University's central job market:

Central job market of the University